An Approximate Bayesian Estimator Suggests Strong, Recurrent Selective Sweeps in Drosophila 英文参考文献.docVIP

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An Approximate Bayesian Estimator Suggests Strong, Recurrent Selective Sweeps in Drosophila 英文参考文献.doc

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An Approximate Bayesian Estimator Suggests Strong, Recurrent Selective Sweeps in Drosophila 英文参考文献

AnApproximateBayesianEstimatorSuggestsStrong, RecurrentSelectiveSweepsinDrosophila JeffreyD.Jensen1*,KevinR.Thornton2,PeterAndolfatto3,4 1SectionofEcology,BehaviorandEvolution,UniversityofCaliforniaSanDiego,LaJolla,California,UnitedStatesofAmerica,2DepartmentofEcologyandEvolutionary Biology,UniversityofCaliforniaIrvine,Irvine,California,UnitedStatesofAmerica,3DepartmentofEcologyandEvolutionaryBiology,PrincetonUniversity,Princeton,New Jersey,UnitedStatesofAmerica,4Lewis-SiglerInstituteforIntegrativeGenomics,PrincetonUniversity,Princeton,NewJersey,UnitedStatesofAmerica Abstract Therecurrentfixationofnewlyarising,beneficialmutationsinaspeciesreduceslevelsoflinkedneutralvariability.Models positing frequent weakly beneficial substitutions or, alternatively, rare, strongly selected substitutions predict similar averageeffectsonlinkedneutralvariability,iftheproductoftherateandstrengthofselectionisheldconstant.Wepropose anapproximateBayesian(ABC)polymorphism-basedestimatorthatcanbeusedtodistinguishbetweenthesemodels,and applyittomulti-locusdatafromDrosophilamelanogaster.Weinvestigatetheextenttowhichinferenceaboutthestrength ofselectionissensitivetoassumptionsabouttheunderlyingdistributionsoftheratesofsubstitutionandrecombination, thestrengthofselection,heterogeneityinmutationrate,aswellasthepopulation’sdemographichistory.Weshowthat assuming fixed values of selection parameters in estimation leads to overestimates of the strength of selection and underestimatesoftherate.WeestimateparametersforanAfricanpopulationofD.melanogaster(?s,2E203,2Nl*2E{04) andcomparethesetopreviousestimates.Finally,weshowthatsurveyinglargergenomicregionsisexpectedtolendmuch more discriminatory power to the approach. It will thus be of great interest to apply this method to emerging whole- genomepolymorphismdatasetsinmanytaxa. ^ Citation: Jensen JD, ThorntonKR, Andolfatto P (2008) An Approximate Bayesian Estimator SuggestsStrong,Recurrent Selective Sweeps in Drosophila. PLoS Genet4(9):e1000198.doi:1