Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NODSCID Mice through High Angiogenic and Engraftment Capabilities 英文参考文献.docVIP
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Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NODSCID Mice through High Angiogenic and Engraftment Capabilities 英文参考文献
AmnioticMesenchymalStemCellsEnhanceWound
HealinginDiabeticNOD/SCIDMicethroughHigh
AngiogenicandEngraftmentCapabilities
Sung-WhanKim1,2*,Hong-ZheZhang1,2,LongzheGuo1,2,Jong-MinKim3,MooHyunKim1,2*
1Regional Clinical Center, Dong-AUniversity Hospital, Busan, South Korea, 2Department ofCardiology, College of Medicine, Dong-A University, Busan, South Korea,
3DepartmentofAnatomyandCellBiology,CollegeofMedicine,Dong-AUniversity,Busan,SouthKorea
Abstract
Althoughhumanamnioticmesenchymalstemcells(AMMs)havebeenrecognisedasapromisingstemcellresource,their
therapeutic potential for wound healing has not been widely investigated. In this study, we evaluated the therapeutic
potentialofAMMsusingadiabeticmousewoundmodel.Quantitativereal-timePCRandELISAresultsrevealedthatthe
angiogenic factors, IGF-1, EGF and IL-8 were markedly upregulated in AMMs when compared with adipose-derived
mesenchymal stem cells (ADMs) and dermal fibroblasts. In vitro scratch wound assays also showed that AMM-derived
conditionedmedia(CM)significantlyacceleratedwoundclosure.Diabeticmiceweregeneratedusingstreptozotocinand
wounds were created by skin excision, followed by AMM transplantation. AMM transplantation significantly promoted
woundhealingandincreasedre-epithelializationandcellularity.Notably,transplantedAMMsexhibitedhighengraftment
ratesandexpressed keratinocyte-specific proteinsandcytokeratin inthewoundarea,indicating adirectcontribution to
cutaneousclosure.Takentogether,thesedatasuggestthatAMMspossessconsiderabletherapeuticpotentialforchronic
woundsthroughthesecretionofangiogenicfactorsandenhancedengraftment/differentiationcapabilities.
Citation:KimS-W,ZhangH-Z,GuoL,KimJ-M,KimMH(2012)AmnioticMesenchymalStemCellsEnhanceWoundHealinginDiabeticNOD/SCIDMicethrough
HighAngiogenicandEngraftmentCapabilities.PLoSONE7(7):e41105.doi:10.1371/journal.pone.0041105
Editor:PaoloFiorina,Children’sHospitalBoston/HarvardMedicalSchool,UnitedStatesofAmerica
ReceivedDecember22,2011;AcceptedJune18,2012;PublishedJuly
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