Alpha-Linolenic Acid Intake and 10-Year Incidence of Coronary Heart Disease and Stroke in 20,000 Middle-Aged Men and Women in The Netherlands 英文参考文献.docVIP

下载本文档

3
0
约 8页
2017-05-11 发布于上海
举报
版权申诉

Alpha-Linolenic Acid Intake and 10-Year Incidence of Coronary Heart Disease and Stroke in 20,000 Middle-Aged Men and Women in The Netherlands 英文参考文献.doc

1、本文档共8页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Alpha-Linolenic Acid Intake and 10-Year Incidence of Coronary Heart Disease and Stroke in 20,000 Middle-Aged Men and Women in The Netherlands 英文参考文献

Alpha-LinolenicAcidIntakeand10-YearIncidenceof CoronaryHeartDiseaseandStrokein20,000Middle- AgedMenandWomeninTheNetherlands JanettedeGoede1,W.M.MoniqueVerschuren2,JolandaM.A.Boer2,DaanKromhout1,JohannaM. Geleijnse1* 1Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, 2National Institute for Public Health and the Environment, Bilthoven, The Netherlands Abstract Background:Whetherintakeofalpha-linolenicacid(ALA),theplant-derivedn-3polyunsaturatedfattyacid(PUFA),could prevent cardiovascular diseases is not yet clear. We examined the associations of ALA intake with 10-year incidence of coronaryheartdisease(CHD)andstrokeintheNetherlands. Methods:Datawerecollectedfromageneralpopulationof20,069generallyhealthymenandwomen,aged20to65years. Habitualdietwasassessedatbaseline(1993–1997)withavalidated178-itemfoodfrequencyquestionnaire.Incidencesof CHDandstrokewereassessedthroughlinkagewithmortalityandmorbidityregisters.Hazardratios(HR)werecalculated withmultivariableCoxproportionalhazardsmodels,adjustedforage,gender,lifestyle,anddietaryfactors. Results:During8–13yearsoffollow-up,weobserved280incidentCHDevents(19%fatal)and221strokes(4%fatal).Intakes ofenergy-adjustedALAinquintilesrangedfromlessthan1.0g/dinthebottomquintile(Q1)tomorethan1.9g/dinthe topquintile(Q5).ALAintakewasnotassociatedwithincidentCHD,withHRsvaryingbetween0.89and1.01(allp.0.05)in Q2–Q5comparedwiththebottomquintileofALAintake.Forincidentstroke,however,participantsinQ2–Q5hada35–50% lowerriskcomparedwiththereferencegroup.HRswere0.65(0.43–0.97),0.49(0.31–0.76),0.53(0.34–0.83),and0.65(0.41– 1.04)forQ2–Q5respectively. Conclusion:InthisgeneralDutchpopulation,ALAintakewasnotassociatedwithincidentCHD.Thedatasuggestedthata lowintakeofALAmaybearisk factorforincidentstroke. Theseresultswarrantconfirmationinotherpopulation-based studiesandintrials. Citation:deGoedeJ,VerschurenWMM,BoerJMA,KromhoutD,GeleijnseJM(2011)Alpha-LinolenicAcidIntakeand10-YearIncidenceofCoronaryHeartDisease andStroke