Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes 英文参考文献.docVIP

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Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes 英文参考文献.doc

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Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes 英文参考文献

Alkannin,HSP70Inducer,ProtectsagainstUVB-Induced ApoptosisinHumanKeratinocytes YokoYoshihisa1,MariameAliHassan2,4,YukihiroFurusawa2,YoshiakiTabuchi3,TakashiKondo2, TadamichiShimizu1* 1Department of Dermatology, Life Science Research Center, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 2DepartmentofRadiologicalSciences,LifeScienceResearchCenter,GraduateSchoolofMedicineandPharmaceuticalSciences,UniversityofToyama,Toyama,Japan, 3DivisionofMolecularGeneticsResearch,LifeScienceResearchCenter,GraduateSchoolofMedicineandPharmaceuticalSciences,UniversityofToyama,Toyama,Japan, 4DepartmentofPharmaceuticsandIndustrialPharmacy,FacultyofPharmacy,CairoUniversity,Cairo,Egypt Abstract AlkanninisanactiveconstituentfromtherootextractofAlkannatinctoriaoftheBoraginaceaefamilyanditmayhaveutility asaheatshockprotein70(HSP70)inducerinlivingorganisms.Here,theeffectsofalkannin-inducedHSP70onultraviolet 2 (UV) B (40mJ/cm )-induced apoptosis were investigated in human keratinocyte HaCaT cells. Pretreatment of cells with alkannin (1mM) caused significant inhibition of UVB-induced apoptosis and caspase-3 cleavage. On the other hand, the addition of KNK437 (HSP70 inhibitor) reversed the action of alkannin increasing UVB-induced apoptosis in a dose- dependentmanner.Inaddition,differencesingeneexpressionassociatedwiththesuppressionofUVB-inducedapoptosis inthepresenceofalkanninwereinvestigatedusingGeneChipassay.OurresultsindicatethatalkanninsuppressesUVB- inducedapoptosisthroughtheinductionofHSP70inhumankeratinocytes,andtherefore,wesuggesttheusefulnessof usingalkanninasanantiagingagent. Citation:YoshihisaY,HassanMA,FurusawaY,TabuchiY,KondoT,etal.(2012)Alkannin,HSP70Inducer,ProtectsagainstUVB-InducedApoptosisinHuman Keratinocytes.PLoSONE7(10):e47903.doi:10.1371/journal.pone.0047903 Editor:AndrzejT.Slominski,UniversityofTennessee,UnitedStatesofAmerica ReceivedMay10,2012;AcceptedSeptember17,2012;PublishedOctober22,2012 Copyright: ? 2012 Yoshihisa et a