Amphetamine Administration into the Ventral Striatum Facilitates Behavioral Interaction with Unconditioned Visual Signals in Rats 英文参考文献.docVIP
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Amphetamine Administration into the Ventral Striatum Facilitates Behavioral Interaction with Unconditioned Visual Signals in Rats 英文参考文献
AmphetamineAdministrationintotheVentralStriatum
FacilitatesBehavioralInteractionwithUnconditioned
VisualSignalsinRats
RickShin,JunranCao,SierraM.Webb,SatoshiIkemoto*
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, United States Department of Health and Human Services,
Baltimore,Maryland,UnitedStatesofAmerica
Abstract
Background:Administrationofpsychomotorstimulantslikeamphetaminefacilitatesbehaviorinthepresenceofincentive
distal stimuli, which have acquired the motivational properties of primary rewards through associative learning. This
facilitationappearstobemediatedbythemesolimbicdopaminesystem,whichmayalsobeinvolvedinfacilitatingbehavior
inthepresenceofdistalstimulithathavenotbeenpreviouslypairedwithprimaryrewards.However,itisunclearwhether
psychomotorstimulantsfacilitatebehavioralinteractionwithunconditioneddistalstimuli.
Principal Findings: We found that noncontingent administration of amphetamine into subregions of the rat ventral
striatum,particularlyinthevicinityofthemedialolfactorytubercle,facilitatesleverpressingfollowedbyvisualsignalsthat
hadnotbeenpairedwithprimaryrewards.Noncontingentadministrationofamphetaminefailedtofacilitateleverpressing
whenitwasfollowedbyeithertonesordelayedpresentationorabsenceofvisualsignals,suggestingthatvisualsignalsare
keyforenhancedbehavioralinteraction.Systemicadministrationofamphetaminemarkedlyincreasedlocomotoractivity,
butdidnotnecessarilyincreaseleverpressingrewardedbyvisualsignals,suggestingthatleverpressingisnotabyproduct
of heightened locomotor activity. Lever pressing facilitated by amphetamine was reduced by co-administration of the
dopaminereceptorantagonistsSCH23390(D1selective)orsulpiride(D2selective).
Conclusions:Ourresultssuggestthatamphetamineadministrationintotheventralstriatum,particularlyinthevicinityof
the medial olfactory tubercle, activates dopaminergic mechanisms that strongly enhance behavioral interaction with
unconditionedvisualstimuli.
Cita
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