An Approach for the Identification of Targets Specific to Bone Metastasis Using Cancer Genes Interactome and Gene Ontology Analysis 英文参考文献.docVIP
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An Approach for the Identification of Targets Specific to Bone Metastasis Using Cancer Genes Interactome and Gene Ontology Analysis 英文参考文献
AnApproachfortheIdentificationofTargetsSpecificto
BoneMetastasisUsingCancerGenesInteractomeand
GeneOntologyAnalysis
ShikhaVashisht,GaneshBagler*
BiotechnologyDivision,InstituteofHimalayanBioresourceTechnology,CouncilofScientificandIndustrialResearch,Palampur,India
Abstract
Metastasisisoneofthemostenigmaticaspectsofcancerpathogenesisandisamajorcauseofcancer-associatedmortality.
Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is
characterizedbyintricateinterplayofmolecularinteractions.IdentificationoftargetsformultifactorialdiseasessuchasSBC,
themostfrequentcomplicationofbreastandprostatecancers,isachallenge.Towardsachievingouraimofidentificationof
targetsspecific toSBC,weconstructeda‘CancerGenesNetwork’,arepresentativeproteininteractome ofcancergenes.
Usinggraphtheoreticalmethods,weobtainedasetofkeygenesthatarerelevantforgenericmechanismsofcancersand
havearoleinbiologicalessentiality.Wealsocompiledacurateddatasetof391SBCgenesfrompublishedliteraturewhich
servesasabasisofontologicalcorrelatesofsecondary bonecancer. Buildingontheseresults,weimplementastrategy
based on generic cancer genes, SBC genes and gene ontology enrichment method, to obtain a set of targets that are
specific to bone metastasis. Through this study, we present an approach for probing one of the major complications in
cancers,namely,metastasis.Theresultsongenesthatplaygenericrolesincancerphenotype,obtainedbynetworkanalysis
of‘CancerGenesNetwork’,havebroaderimplicationsinunderstandingtheroleofmolecularregulatorsinmechanismsof
cancers. Specifically, our study provides a set of potential targets that are of ontological and regulatory relevance to
secondarybonecancer.
Citation: Vashisht S, Bagler G (2012) An Approach for the Identification of Targets Specific to Bone Metastasis Using Cancer Genes Interactome and Gene
OntologyAnalysis.PLoSONE7(11):e49401.doi:10.1371/journal.pone.0049401
Editor:MatthiasDehmer,UMIT,Austria
ReceivedJ
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