An Association Analysis between Mitochondrial DNA A10398G Polymorphism and Temperament in Japanese Young Adults 英文参考文献.docVIP
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An Association Analysis between Mitochondrial DNA A10398G Polymorphism and Temperament in Japanese Young Adults 英文参考文献
AnAssociationAnalysisbetweenMitochondrialDNA
A10398GPolymorphismandTemperamentinJapanese
YoungAdults
KunihiroKishida1*,MihokoTominaga1,KiminoriMatsubara2,MasanoriTaguchi3,MasanoriNoguchi4,
NoriakiTsunawake1,YoshihiroShidoji1
1GraduateSchoolofHumanHealthSciences,UniversityofNagasaki,Siebold,Nagayo,Nagasaki,Japan,2GraduateSchoolofEducation,HiroshimaUniversity,Higashi-
Hiroshima,Hiroshima,Japan,3DepartmentofLanguageandCulture,DokkyoUniversity,Soka-shi,Saitama,Japan,4DepartmentofGeneralEducation,SaseboNational
CollegeofTechnology,Sasebo,Nagasaki,Japan
Abstract
The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental
disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are
poorly understood. Evaluating healthy subjects can have the advantage of providing new strategies for maintaining
psychological health and preventing mental illness. We examined the association between mtDNA polymorphisms and
temperament in Japanese students. There was no significant difference in examined temperament when analysed by
genotypes, 5178–10398 haplotypes, or sex. The subgroup analysis based on sex indicated that there was an interactive
effect of the mtDNA A10398G polymorphism and sex on anxiety and obsession. This finding is preliminary and cannot
exclude the possibility of false-positive due to small sample size (144 subjects) and multiple statistical testing. Further
studiesinvolvingalargersamplesizeorotherethnicgroupsarenecessarytoconfirmthatmtDNAA10398Gpolymorphism
canbeageneticfactorfortemperament.
Citation:KishidaK,TominagaM,MatsubaraK,TaguchiM,NoguchiM,etal.(2009)AnAssociationAnalysisbetweenMitochondrialDNAA10398GPolymorphism
andTemperamentinJapaneseYoungAdults.PLoSONE4(11):e7763.doi:10.1371/journal.pone.0007763
Editor:TadafumiKato,RIKENBrainScienceInstitution,Japan
ReceivedAugust4,2009;AcceptedOctober14,2009;PublishedNovember9,2009
Copyright: ? 2009 Kishida et al. This
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