Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in Postreplication Repair Pathway in S. cerevisiae 英文参考文献.docVIP

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Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in Postreplication Repair Pathway in S. cerevisiae 英文参考文献.doc

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Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in Postreplication Repair Pathway in S. cerevisiae 英文参考文献

Anc1,aProteinAssociatedwithMultipleTranscription Complexes,IsInvolvedinPostreplicationRepairPathway inS.cerevisiae RachelL.Erlich1,2¤a,RebeccaC.Fry1,2¤b,ThomasJ.Begley2,3¤c,DanielleL.Daee4,RobertS.Lahue4¤d, LeonaD.Samson1,2,3 * 1Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 2Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3Department of Biological Engineering, Massachusetts Institute of Technology,Cambridge,Massachusetts,UnitedStatesofAmerica,4EppleyInstituteforResearchinCancerandAlliedDiseases,UniversityofNebraskaMedicalCenter, Omaha,Nebraska,UnitedStatesofAmerica Abstract YeaststrainslackingAnc1,amemberoftheYEATSproteinfamily,aresensitivetoseveralDNAdamagingagents.TheYEATS familyincludestwohumangenesthatarecommonfusionpartnerswithMLLinhumanacuteleukemias.Anc1isamember ofsevenmulti-proteincomplexesinvolvedintranscription,andthedamagesensitivityobservedinanc1Dcellsismirrored instrainsdeletedforsomeothernon-essentialmembersofseveralofthesecomplexes.HereweshowthatANC1isinthe same epistasis group as SRS2 and RAD5, members of the postreplication repair (PRR) pathway, but has additive or synergisticinteractionswithseveralothermembersofthispathway.AlthoughPRRistraditionallydividedintoan‘‘error- prone’’andan‘‘error-free’’branch,ANC1isnotepistaticwithallmembersofeitherestablishedbranch,andinsteaddefinesa newerror-freebranchofthePRRpathway.LikeseveralgenesinvolvedinPRR,anintactANC1genesignificantlysuppresses spontaneousmutationrates,includingtheexpansionof(CAG)25repeats.Anc1’sroleinthePRRpathway,aswellasitsrole insuppressingtripletrepeats,pointtoapossiblemechanismforaproteinofpotentialmedicalinterest. Citation: Erlich RL, Fry RC, Begley TJ, Daee DL, Lahue RS, et al. (2008) Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in PostreplicationRepairPathwayinS.cerevisiae.PLoSONE3(11):e3717.doi:10.13