Analysis of Pulmonary Inflammation and Function in the Mouse and Baboon after Exposure to Mycoplasma pneumoniae CARDS Toxin 英文参考文献.docVIP

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Analysis of Pulmonary Inflammation and Function in the Mouse and Baboon after Exposure to Mycoplasma pneumoniae CARDS Toxin 英文参考文献.doc

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Analysis of Pulmonary Inflammation and Function in the Mouse and Baboon after Exposure to Mycoplasma pneumoniae CARDS Toxin 英文参考文献

AnalysisofPulmonaryInflammationandFunctioninthe MouseandBaboonafterExposuretoMycoplasma pneumoniaeCARDSToxin R.DougHardy4,6,JacquelineJ.Coalson3,5,JayPeters2,5,AdrianaChaparro1,5 ,Chonnamet Techasaensiri4,6,AngeleneM.Cantwell1,5,T.R.Kannan1,5,JoelB.Baseman1,5,PeterH.Dube1,5 * 1DepartmentofMicrobiologyandImmunology,UniversityofTexasHealthSciencesCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica,2Department ofMedicine,DivisionofPulmonaryandCriticalCareMedicine,UniversityofTexasHealthSciencesCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica, 3DepartmentofPathology,UniversityofTexasHealthSciencesCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica,4DepartmentofInternalMedicine andPediatricInfectiousDiseases,UniversityofTexasHealthSciencesCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica,5UniversityofTexasHealth SciencesCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica,6UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,UnitedStatesofAmerica Abstract MycoplasmapneumoniaeproducesanADP-ribosylatingandvacuolatingtoxinknownastheCARDS(CommunityAcquired RespiratoryDistressSyndrome)toxinthathasbeenshowntobecytotoxictomammaliancellsintissueandorganculture.In thisstudywetestedtheabilityofrecombinantCARDS(rCARDS)toxintoelicitchangeswithinthepulmonarycompartment inbothmiceandbaboons.AnimalsrespondedtoarespiratoryexposuretorCARDStoxininadoseandactivity-dependent mannerbyincreasingtheexpressionofthepro-inflammatorycytokinesIL-1a,1b,6,12,17,TNF-aandIFN-c.Therewasalso adose-dependentincreaseinseveralgrowthfactorsandchemokinesfollowingtoxinexposureincludingKC,IL-8,RANTES, andG-CSF.IncreasedexpressionofIFN-cwasobservedonlyinthebaboon;otherwise,miceandbaboonsrespondedto CARDStoxininaverysimilarmanner.IntroductionofrCARDStoxintotheairwaysofmiceorbaboonsresultedinacellular inflammatory response characterized by a dose-dependent early vacuolization and cytotoxicity of the bronchiolar epitheliumfollowedbyarobustperibronchialandperivascularlymphocyti