Androgen Regulated Genes in Human Prostate Xenografts in Mice Relation to BPH and Prostate Cancer 英文参考文献.docVIP

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Androgen Regulated Genes in Human Prostate Xenografts in Mice Relation to BPH and Prostate Cancer 英文参考文献.doc

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Androgen Regulated Genes in Human Prostate Xenografts in Mice Relation to BPH and Prostate Cancer 英文参考文献

AndrogenRegulatedGenesinHumanProstate XenograftsinMice:RelationtoBPHandProstateCancer HaroldD.Love1,S.ErinBooton2,BradenE.Boone3,JoanP.Breyer4,TatsukiKoyama5,7,MonicaP. Revelo10,ScottB.Shappell1,6,11,JeffreyR.Smith4,5,8,9,SimonW.Hayward1,7,8 * 1DepartmentofUrologicSurgery,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,UnitedStatesofAmerica,2DermatologyDivision,VanderbiltUniversity School of Medicine, Nashville, Tennessee, United States of America, 3Vanderbilt Microarray Shared Resource, Vanderbilt University School of Medicine, Nashville, Tennessee,UnitedStatesofAmerica,4DepartmentofMedicine,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,UnitedStatesofAmerica,5Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 6Department of Pathology, Vanderbilt University School of Medicine,Nashville,Tennessee,UnitedStatesofAmerica,7TheVanderbilt-IngramCancerCenter,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,United StatesofAmerica,8DepartmentofCancerBiology,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,UnitedStatesofAmerica,9MedicalResearchService, VATennesseeValleyHealthcareSystem,Nashville,Tennessee,UnitedStatesofAmerica,10DepartmentofPathologyandLaboratoryMedicine,UniversityofUtah,Salt LakeCity,Utah,UnitedStatesofAmerica,11AveroDiagnostics,Dallas,Texas,UnitedStatesofAmerica Abstract Benign prostatic hyperplasia (BPH) and prostate carcinoma (CaP) are linked to aging and the presence of androgens, suggestingthatandrogenregulatedgenesplayamajorroleinthesecommondiseases.Androgenregulationofprostate growthanddevelopmentdependsonthepresenceofintactepithelial-stromalinteractions.Further,theprostaticstromais implicatedinBPH.Thissuggeststhatepithelialcelllinesareinadequatetoidentifyandrogenregulatedgenesthatcould contributetoBPHandCaPandwhichcouldserveaspotentialclinicalbiomarkers.Inthisstudy,weusedahumanprostate xenograftmodeltodefineaprofileofgenesregulatedinvivobyandrogen