Analysis of the Interferon Gamma (rs2430561, +874TA) Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid Arthritis 英文参考文献.docVIP

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Analysis of the Interferon Gamma (rs2430561, +874TA) Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid Arthritis 英文参考文献.doc

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AnalysisoftheInterferonGamma(rs2430561,874TA)FunctionalGeneVariantinRelationtothePresenceofCardiovascularEventsinRheumatoidArthritis英文参考文献

AnalysisoftheInterferonGamma(rs2430561,+874T/A) FunctionalGeneVariantinRelationtothePresenceof CardiovascularEventsinRheumatoidArthritis MercedesGarc?′a-Bermu′dez1.,RaquelLo′pez-Mej?′as2.,CarlosGonza′lez-Juanatey3,AlfonsoCorrales2, GemaRobledo1,SantosCastan?eda4,Jose′ A.Miranda-Filloy5,RicardoBlanco2,Benjam?′nFerna′ndez- Gutie′rrez6,AlejandroBalsa7,IsidoroGonza′lez-Alvaro4,CarmenGo′mez-Vaquero8,JavierLlorca9, JavierMart?′n1,MiguelA.Gonza′lez-Gay2* 1InstitutodeParasitolog?′ayBiomedicinaLo′pez-Neyra,ConsejoSuperiordeInvestigacionesCient?′ficas,IPBLN-C.S.I.C.,Granada,Spain,2DepartmentofRheumatology, HospitalUniversitarioMarque′sdeValdecilla,IFIMAV,Santander,Spain,3CardiologyDivision,HospitalXeral-Calde,Lugo,Spain,4DepartmentofRheumatology,Hospital UniversitarioLaPrincesa,IIS-Princesa,Madrid,Spain,5DepartmentofRheumatology,HospitalXeral-Calde,Lugo,Spain,6DepartmentofRheumatology,HospitalCl?′nico San Carlos, Madrid, Spain, 7Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, 8Department of Rheumatology, Hospital Universitario de Bellvitge,IDIBELL,LHospitaletdelLlobregat,Barcelona,Spain,9DepartmentofEpidemiologyandComputationalBiology,SchoolofMedicine,UniversityofCantabria,and CIBEREpidemiolog?′aySaludPu′blica(CIBERESP),IFIMAV,Santander,Spain Abstract Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) morbidityandmortality.Sinceinterferon-gamma(IFN-c)hasadirecteffectoninflammation,inthisstudyweassessedthe potentialassociationoftheIFNGfunctionalgenevariantrs2430561withCVdiseaseinpatientswithRA. Methods: One thousand six hundred and thirty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for RA were genotyped for the IFNG (rs2430561, +874T/A) gene polymorphism using TaqMan genotyping assay. Patients were stratified according to the presence of CV events or not. Logistic regression models to explain the presence of CV disease according to the