Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways 英文参考文献.docVIP

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Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways 英文参考文献.doc

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Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways 英文参考文献

o PL SMEDICINE AnalysisofGermlineGLI1Variation ImplicatesHedgehogSignallinginthe RegulationofIntestinalInflammatoryPathways Charlie W. Lees1,2*[,William J.Zacharias3[,Mark Tremelling4,Colin L.Noble1,Elaine R.Nimmo1,Albert Tenesa5, Jennine Cornelius6,Leif Torkvist7,John Kao8,Susan Farrington5,Hazel E.Drummond1,Gwo-Tzer Ho1,Ian D.R.Arnott1, Henry D.Appelman9,Lauri Diehl6,Harry Campbell5,Malcolm G.Dunlop5,Miles Parkes4,Sarah E.M. Howie2, Deborah L.Gumucio3*},Jack Satsangi1} 1GastrointestinalUnit,MolecularMedicineCentre,UniversityofEdinburgh,Edinburgh,UnitedKingdom,2ImmunobiologyGroup,MedicalResearchCouncil(MRC)Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, 3 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 4 Inflammatory Bowel Disease (IBD) Research Group, Addenbrooke’s Hospital, UniversityofCambridge,Cambridge,UnitedKingdom,5ColonCancerGeneticsGroup,MRCHumanGeneticsUnit,WesternGeneralHospital,Edinburgh,UnitedKingdom, 6DepartmentofPathology, Genentech,Inc,SouthSanFrancisco,California,United StatesofAmerica, 7Department ofMedicalSurgicalGastroenterology,Karolinska University Hospital, Stockholm, Sweden, 8 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 9 DepartmentofPathology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,UnitedStatesofAmerica Funding:Seesectionatendof manuscript. ABSTRACT CompetingInterests:Seesectionat endofmanuscript. Background AcademicEditor:LudvigSollid, UniversityofOslo,Norway Ulcerative colitis (UC) and Crohn’s disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with considerable morbidity. The hedgehog(HH)signallingpathway,whichincludesthetranscriptionfactorglioma-associated oncogene homolog 1 (GLI1), plays vital roles in gastrointestinal tract