Analysis of Intron Sequence Features Associated with Transcriptional Regulation in Human Genes 英文参考文献.docVIP

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Analysis of Intron Sequence Features Associated with Transcriptional Regulation in Human Genes 英文参考文献.doc

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Analysis of Intron Sequence Features Associated with Transcriptional Regulation in Human Genes 英文参考文献

AnalysisofIntronSequenceFeaturesAssociatedwith TranscriptionalRegulationinHumanGenes HuiminLi1,3.,DanChen1,2.,JingZhang2* 1LaboratoryforConservationandUtilizationofBio-resources,YunnanUniversity,Kunming,China,2SchoolofMathematicsandStatistics,YunnanUniversity,Kunming, China,3SchoolofMathematicsandComputerScience,YunnanUniversityofNationalities,Kunming,China Abstract Althoughsomepreliminaryworkhasrevealedthepotentialtranscriptionalregulatoryfunctionoftheintronsineukaryotes, additionalevidencesareneededtosupportthisconjecture.Inthisstudy,weperformsystemicanalysesofthesequence characteristicsofhumanintrons.TheresultsshowthatthefirstintronsaregenerallylongerandC,Gandtheirdinucleotide compositionsareover-representedrelativetootherintrons,whichareconsistentwiththepreviousfindings.Inaddition, somenewphenomenaconcernedwithtranscriptionalregulationarefound:i)thefirstintronsareenrichedinCpGislands; andii)thepercentagesofthefirstintronscontainingTATA,CAATandGCboxesarerelativelyhigherthanotherposition introns.Thesimilarfeaturesofintronsareobservedintissue-specificgenes.Theresultsfurthersupportthatthefirstintrons ofhumangenesarelikelytobeinvolvedintranscriptionalregulation,andgiveaninsightintothetranscriptionalregulatory regionsofgenes. Citation:LiH,ChenD,ZhangJ(2012)AnalysisofIntronSequenceFeaturesAssociatedwithTranscriptionalRegulationinHumanGenes.PLoSONE7(10):e46784. doi:10.1371/journal.pone.0046784 Editor:DmitryINurminsky,UniversityofMarylandSchoolofMedicine,UnitedStatesofAmerica ReceivedMarch13,2012;AcceptedSeptember6,2012;PublishedOctober17,2012 Copyright:?2012Lietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work is supported by grants from the Science Foundation of Yunnan Province (2007A023M) and a grant from the National Natural Science FoundationofChina.Thefundershadnoroleinstudydesig