Are Anticapsular Antibodies the Primary Mechanism of Protection against Invasive Pneumococcal Disease 英文参考文献.docVIP

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Are Anticapsular Antibodies the Primary Mechanism of Protection against Invasive Pneumococcal Disease 英文参考文献.doc

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Are Anticapsular Antibodies the Primary Mechanism of Protection against Invasive Pneumococcal Disease 英文参考文献

o Openaccess,freelyavailableonline PL S MEDICINE AreAnticapsularAntibodiesthePrimary MechanismofProtectionagainstInvasive PneumococcalDisease? Marc Lipsitch1*,Cynthia G. Whitney2,Elizabeth Zell2,Tarja Kaijalainen3,Ron Dagan4,Richard Malley5 1Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2Active Bacterial Core Surveillance and Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,UnitedStatesofAmerica,3NationalReferenceLaboratoryforPneumococcus,NationalPublicHealthInstitute,Oulu,Finland,4PediatricInfectiousDiseaseUnit, Soroka University MedicalCenter andthe FacultyofHealth Sciences, Ben-GurionUniversity ofthe Negev, Beer-Sheva, Israel, 5Children’sHospitaland HarvardMedical School,Boston,Massachusetts,UnitedStatesofAmerica ABSTRACT CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. Background AuthorContributions:MLandRM designedthestudy.TKandRD conductedthestudies.MLandEZ Antibody to capsular polysaccharide has been the basis of several vaccines that offer protection against invasive disease from Streptococcus pneumoniae. The success of such vaccineshasledtotheinferencethatnaturalprotectionagainstinvasivepneumococcaldisease islargelyconferredbyanticapsularantibody.Ifthisisso,onewouldexpectthatthedeclinein disease from different serotypes would vary significantly, and that the appearance of substantial concentrations of anticapsular antibodies would coincide temporally with the declineinage-specificincidence. analyzedthedata.CGW,EZ,and theActiveBacterialCoreSurveil- lanceTeamcontributedreagents/ materials/analysistools.ML,RM, CGW,andRDcontributedto writingthepaper.Themembersof theActiveBacterialCoreSurveil- lanceTeamarelistedintheAc- knowledgments. MethodsandFindings AcademicEditor:BrianGreen- wood,UniversityofLondon, UnitedKingdom Usingincidence