Assessment of the Potential Role of Muscle Spindle Mechanoreceptor Afferents in Chronic Muscle Pain in the Rat Masseter Muscle 英文参考文献.docVIP
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Assessment of the Potential Role of Muscle Spindle Mechanoreceptor Afferents in Chronic Muscle Pain in the Rat Masseter Muscle 英文参考文献
AssessmentofthePotentialRoleofMuscleSpindle
MechanoreceptorAfferentsinChronicMusclePaininthe
RatMasseterMuscle
JamesP.Lund1,3{,SomayehSadeghi3,TuijaAthanassiadis4,NadiaCaramSalas3,Franc?oisAuclair1,
Beno??tThivierge2,IsabelArsenault1,PierreRompre′2,Karl-GunnarWestberg4,ArletteKolta1,2,3*
1Groupe de Recherche sur le Syste`me Nerveux Central du Fonds de Recherche en Sante′ du Que′bec, Department of Physiology, Universite′ de Montre′al, Montre′al,
Que′bec,Canada,2DepartmentofStomatology,Universite′ deMontre′al, Montre′al, Que′bec,Canada,3FacultyofDentistry,McGillUniversity,Montre′al, Que′bec,Canada,
4SectionforPhysiology,DepartmentofIntegrativeMedicalBiology,Umea? University,Umea?, Sweden
Abstract
Background:Thephenotypeoflargediametersensoryafferentneuronschangesinseveralmodelsofneuropathicpain.We
askedifsimilarchangesalsooccurin‘‘functional’’painsyndromes.
Methodology/Principal Findings: Acidic saline (AS, pH4.0) injections into the masseter muscle were used to induce
persistentmyalgia.ControlsreceivedsalineatpH7.2.NocifensiveresponsesofExperimentalratstoapplicationsofVonFrey
Filamentstothemasseterswereabovecontrollevels1–38dayspost-injection.Thiseffectwasbilateral.Expressionofc-Fos
intheTrigeminalMesencephalicNucleus(NVmes),whichcontainsthesomataofmassetermusclespindleafferents(MSA),
wasabovebaselinelevels1and4daysafterAS.TherestingmembranepotentialsofneuronsexposedtoAS(n=167)were
hyperpolarizedwhencomparedtotheircontrolcounterparts(n=141),asweretheirthresholdsforfiring,highfrequency
membrane oscillations (HFMO), bursting, inward and outward rectification. The amplitude of HFMO was increased and
spontaneousectopicfiringoccurredin10%ofacid-exposedneurons,butneverinControls.Thesechangesappearedwithin
the same time frame as the observed nocifensive behaviour. Ectopic action potentials can travel centrally, but also
antidromically to the peripheral terminals of MSA where they could cause neurotransmitter release and activation of
adjacentfibreterminals.Usingim
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