Association between Human Papillomavirus and Human T-Lymphotropic Virus in Indigenous Women from the Peruvian Amazon 英文参考文献.docVIP

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Association between Human Papillomavirus and Human T-Lymphotropic Virus in Indigenous Women from the Peruvian Amazon 英文参考文献.doc

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Association between Human Papillomavirus and Human T-Lymphotropic Virus in Indigenous Women from the Peruvian Amazon 英文参考文献

AssociationbetweenHumanPapillomavirusandHuman T-LymphotropicVirusinIndigenousWomenfromthe PeruvianAmazon MagalyM.Blas1*.,IsaacE.Alva1.,PatriciaJ.Garcia1,CesarCarcamo1,SilviaM.Montano2, RicardoMun?ante3,JosephR.Zunt4,5 1Epidemiology,STDandHIVUnit,SchoolofPublicHealthandAdministration,UniversidadPeruanaCayetanoHeredia,Lima,Peru,2USNavalMedicalResearchUnitNo.6 (NAMRU-6), Lima, Peru, 3Ucayali Regional Health Directorate, Ministry of Health, Ucayali, Peru, 4Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, United States of America, 5Department of Neurology, Global Health and Medicine, School of Medicine, University of Washington, Seattle,Washington,UnitedStatesofAmerica Abstract Background: No association between the Human T-cell lymphotropic virus (HTLV), an oncogenic virus that alters host immunity,andtheHumanPapillomavirus(HPV)haspreviouslybeenreported.Examiningtheassociationbetweenthese twovirusesmaypermittheidentificationofapopulationatincreasedriskfordevelopingcervicalcancer. MethodsandFindings:BetweenJuly2010andFebruary2011,weconductedacross-sectionalstudyamongindigenous AmazonianPeruvianwomenfromtheShipibo-Koniboethnicgroup,agroupwithendemicHTLVinfection.Werecruited womenbetween15and39yearsofagewhowerelivinginthecitiesofLimaandUcayali.Ourobjectivesweretodetermine the association between HTLV and: (i) HPV infection of any type, and (ii) high-risk HPV type infection. Sexually active Shipibo-KonibowomenwerescreenedforHTLV-1andHTLV-2infections.AllHTLV-1or-2positivewomen,alongwithtwo community-matchedHTLVnegativesexuallyactiveShipibo-KonibocontrolswerelatertestedforthepresenceofHPVDNA, conventional cytology, and HIV. We screened 1,253 Shipibo-Konibo women, observing a prevalence of 5.9% (n=74) for HTLV-1and3.8%(n=47)forHTLV-2infections.Weenrolled62(60.8%)HTLV-1positivewomen,40(39.2%)HTLV-2positive women,and205community-matchedHTLVnegativecontrols.HTLV-1infectionwasstronglyassociatedwithHPVinfection ofanytype(43.6%vs.