Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients 英文参考文献.docVIP

AssociationofNT-proBNPandMultipleBiomarkerswith SeverityofAngiographicCoronaryArteryDiseasein DiabeticandPre-DiabeticChinesePatients ZhouFang2,4,LinuoZhou1*.,YuanyuanBao1,WeiDing1,HaimingShi3*.,XinpingLuo3,RenmingHu1 1DepartmentofEndocrinologyandMetabolism,HuashanHospitalofFudanUniversity,Shanghai,China,2InstituteofEndocrinologyandDiabeteology,Shanghai,China, 3DepartmentofCardiology,HuashanHospitalatFudanUniversity,Shanghai,China,4StateKeyLaboratoryofGeneticEngineering,Shanghai,China Abstract Background: Little is known about the plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), and the relationshipbetweentheseverityofcoronaryheartdisease(CHD)withNT-proBNPandmultiplebiomarkersindiabeticand pre-diabeticpatients,comparedtoindividualswithnormalglucoselevels. Methods:FourhundredandfifteenconsecutiveChinesepatientsofbothsexeswereassignedtothreegroupsonthebasis ofthenewhemoglobin(Hb)A1c(HbA1c)cut-offpointsfordiagnosisofdiabetesandpre-diabetes.Thethreegroupswere divided into tertiles according to NT-proBNP, hs-CRP, cystatin C, and troponin T levels. Gensini scores were compared among the three groups and biomarker tertiles. Receiver operating characteristic (ROC) curves were used to obtain the angiographic CHD cut-off points for each biomarker. Stepwise multivariate linear correlation analysis was applied to examinetheassociationbetweentheseverityofCHDandbiomarkerlevels. Results: Gensini scores increased with increasing biomarker tertile levels and HbA1c. Gensini scores were significantly differentinthemiddleandupperNT-proBNPtertilesofthediabetic,pre-diabeticandcontrolgroups.NT-proBNPhadthe highestpositiveandnegativepredictive valuesandareaunder thecurveforCHD.Only NT-proBNPwasidentified asan independentvariableforGensiniscore. Conclusions: PlasmaNT-proBNPmay beanimportantbiomarker toevaluatetheseverity ofCHDandscreenforCHDin diabeticorpre-diabeticpatients. Citation:FangZ,ZhouL,BaoY,DingW,ShiH,etal.(2011)AssociationofNT-proBNPandMultipleBiom