Association of Typical versus Atypical Antipsychotics with Symptoms and Quality of Life in Schizophrenia 英文参考文献.docVIP

AssociationofTypicalversusAtypicalAntipsychotics withSymptomsandQualityofLifeinSchizophrenia KoichiroFujimaki1*,TerumichiTakahashi2,ShigeruMorinobu3 1FacultyofHealthandWelfare,PrefecturalUniversityofHiroshima,Hiroshima,Japan,2MiharaHospital,Hiroshima,Japan,3ProgramsforBiomedicalResearch,Division ofFrontierMedicalScience,DepartmentofPsychiatryandNeurosciences,GraduateSchoolofBiomedicalSciences,HiroshimaUniversity,Hiroshima,Japan Abstract Background:Severalreportsonpatientswithchronicschizophreniasuggestthatatypicalversustypicalantipsychoticsare expectedtoleadtobetterqualityoflife(QOL)andcognitivefunction.Ouraimwastoexaminetheassociationofchronic treatment with typical or atypical antipsychotics with cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidalsymptomsinlong-hospitalizedpatientswithschizophrenia. MethodologyandPrincipalFindings:TheHasegawaDementiaScale-Revised(HDS-R),BriefPsychiatricRatingScale(BPRS), theSchizophreniaQualityofLifeScale,translatedintoJapanese(JSQLS),andtheDrug-InducedExtrapyramidalSymptoms Scale (DIEPSS) were used to evaluate cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidal symptoms. We examined the correlation between the dose of antipsychotics and each measure derived from these psychometric tests. The student t-test was used to compare scores obtained from psychometric tests between patients receiving typical and atypical antipsychotics. Results showed significant correlations between chlorpromazine (CPZ)- equivalentdosesoftypicalantipsychoticsandatypicalantipsychotics,andthetotalBPRSscoreandBPRSsubscalescoresfor positive symptoms. CPZ-equivalent doses of typical antipsychotics were correlated with the JSQLS subscale score for dysfunctionofpsycho-socialactivityandDIEPSSscore.Furthermore,thetotalBPRSscores,BPRSsubscalescoreforpositive symptoms,theJSQLSsubscalescorefordysfunctionofpsycho-socialactivity,andtheDIEPSSscoreweresignificantlyhigher inpatientsreceivingtypicalantipsychoticsthan