ATP-Dependent Infra-Slow (0.1 Hz) Oscillations in Thalamic Networks 英文参考文献.docVIP

ATP-DependentInfra-Slow(,0.1Hz)Oscillationsin ThalamicNetworks MagorL.Lo?rincz,FreyaGeall¤,YingBao,VincenzoCrunelli,StuartW.Hughes* SchoolofBiosciences,CardiffUniversity,Cardiff,UnitedKingdom Abstract AnincreasingnumberofEEGandrestingstatefMRIstudiesinbothhumansandanimalsindicatethatspontaneouslow frequencyfluctuationsincerebralactivityat,0.1Hz(infra-slowoscillations,ISOs)representafundamentalcomponentof brainfunctioning,beingknowntocorrelatewithfasterneuronalensembleoscillations,regulatebehaviouralperformance and influence seizure susceptibility. Although these oscillations have been commonly indicated to involve the thalamus theirbasiccellularmechanismsremainpoorlyunderstood.Hereweshowthatvariousnucleiinthedorsalthalamusinvitro can express a robust ISO at ,0.005–0.1Hz that is greatly facilitated by activating metabotropic glutamate receptors (mGluRs)and/orAchreceptors(AchRs).ThisISOisaneuronalpopulationphenomenonwhichmodulatesfastergapjunction (GJ)-dependentnetworkoscillations,andcanunderlieepilepticactivitywhenAchRsormGluRsarestimulatedexcessively.In individualthalamocorticalneuronstheISOisprimarilyshapedbyrhythmic,long-lastinghyperpolarizingpotentialswhich 2+ + reflecttheactivationofA1receptors,byATP-derivedadenosine,andsubsequentopeningofBa -sensitiveK channels.We arguethatthisISOhasalikelynon-neuronaloriginandmaycontributetoshapingISOsintheintactbrain. Citation:Lo?rinczML,GeallF,BaoY,CrunelliV,HughesSW(2009)ATP-DependentInfra-Slow(,0.1Hz)OscillationsinThalamicNetworks.PLoSONE4(2):e4447. doi:10.1371/journal.pone.0004447 Editor:ChristophKleinschnitz,Julius-Maximilians-Universita¨t Wu¨rzburg,Germany ReceivedOctober23,2008;AcceptedDecember8,2008;PublishedFebruary12,2009 Copyright: ? 2009 Lo?rincz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbytheWe