Augmented TLR2 Expression on Monocytes in both Human Kawasaki Disease and a Mouse Model of Coronary Arteritis 英文参考文献.docVIP
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Augmented TLR2 Expression on Monocytes in both Human Kawasaki Disease and a Mouse Model of Coronary Arteritis 英文参考文献
AugmentedTLR2ExpressiononMonocytesinboth
HumanKawasakiDiseaseandaMouseModelof
CoronaryArteritis
I-ChunLin1,Ho-ChangKuo1,Ying-JuiLin1,Feng-ShenWang2*,LinWang1,Shun-ChenHuang3 ,Shao-
JuChien1,Chien-FuHuang1,Chih-LuWang4,Hong-RenYu1,Rong-FuChen5,KuenderD.Yang5*
1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and the Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung
University, Kaohsiung, Taiwan, 2Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and the Graduate Institute of Clinical Medical Sciences,
CollegeofMedicine,ChangGungUniversity,Kaohsiung,Taiwan,3DepartmentofPathology,KaohsiungChangGungMemorialHospitalandtheGraduateInstituteof
ClinicalMedicalSciences,CollegeofMedicine,ChangGungUniversity,Kaohsiung,Taiwan,4DepartmentofPediatrics,Po-JenHospital,Kaohsiung,Taiwan,5Department
ofMedicalResearch,ShowChwanMemorialHospitalinChangBing,Changhua,Taiwan
Abstract
Background:Kawasakidisease(KD)ofunknownimmunopathogenesisisanacutefebrilesystemicvasculitisandtheleading
causeofacquiredheartdiseasesinchildhood.TosearchforabetterstrategyforthepreventionandtreatmentofKD,this
studycomparedandvalidatedhumanKDimmunopathogenesisinamousemodelofLactobacilluscaseicellwallextract
(LCWE)-inducedcoronaryarteritis.
Methods:RecruitedsubjectsfulfilledthecriteriaofKDandwereadmittedforintravenousgammaglobulin(IVIG)treatment
attheKaohsiungChangGungMemorialHospitalfrom2001to2009.BloodsamplesfromKDpatientswerecollectedbefore
and after IVIG treatment, and cardiovascular abnormalities were examined by transthoracic echocardiography. Wild-type
male BALB/c mice (4-week-old) were intraperitoneally injected with LCWE (1mg/mL) to induce coronary arteritis. The
inducedimmuneresponseinmicewasexaminedondays1,3,7,and14postinjections,andhistopathologystudieswere
performedondays7and14.
Results: Both human KD patients and LCWE-treated mice developed coronary arteritis, myocarditis, valvulitis, and
pericarditis,aswellaselevatedplasmalevelsof
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