Astrocyte-Derived Tissue Transglutaminase Interacts with Fibronectin A Role in Astrocyte Adhesion and Migration 英文参考文献.docVIP

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Astrocyte-Derived Tissue Transglutaminase Interacts with Fibronectin A Role in Astrocyte Adhesion and Migration 英文参考文献.doc

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Astrocyte-Derived Tissue Transglutaminase Interacts with Fibronectin A Role in Astrocyte Adhesion and Migration 英文参考文献

Astrocyte-DerivedTissueTransglutaminaseInteracts withFibronectin:ARoleinAstrocyteAdhesionand Migration? MiriamE.vanStrien1¤a,JohnJ.P.Breve′1,SilvinaFratantoni1¤b,MarcoW.J.Schreurs2,JohnG.J.M.Bol1, CornelisA.M.Jongenelen1,BenjaminDrukarch1,Anne-MarievanDam1* 1Department of Anatomy and Neurosciences, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands, 2Department of Pathology,VUUniversityMedicalCenter,NeuroscienceCampusAmsterdam,Amsterdam,TheNetherlands Abstract Animportantneuropathologicalfeatureofneuroinflammatoryprocessesthatoccurduringe.g.MultipleSclerosis(MS)isthe formationofanastroglialscar.Astroglialscarformationisfacilitatedbytheinteractionbetweenastrocytesandextracellular matrix proteins (ECM) such as fibronectin. Since there is evidence indicating that glial scars strongly inhibit both axon growth and (re)myelination in brain lesions, it is important to understand the factors that contribute to the interaction betweenastrocytesandECMproteins.TissueTransglutaminase(TG2)isamultifunctionalenzymewithanubiquitoustissue distribution,beingclearlypresentwithinthebrain.IthasbeenshownthatinflammatorycytokinescanenhanceTG2activity. In addition, TG2 can mediate cell adhesion and migration and it binds fibronectin with high affinity. We therefore hypothesizedthatTG2isinvolvedinastrocyte-fibronectininteractions.Ourstudiesusingprimaryratastrocytesshowthat intracellularandcellsurfaceexpressionandactivityofTG2isincreasedaftertreatmentwithpro-inflammatorycytokines. Astrocyte-derived TG2 interacts with fibronectin and is involved in astrocyte adhesion onto and migration across fibronectin.TG2isinvolvedinstimulatingfocaladhesionformationwhichisnecessaryfortheinteractionofastrocyteswith ECMproteins.Weconcludethatastrocyte-derivedTG2contributestotheinteractionbetweenastrocytesandfibronectin.It mighttherebyregulateECMremodelingandpossiblyglialscarring. Citation:vanStrienME,Breve′ JJP,FratantoniS,SchreursMWJ,BolJGJM,etal.(2011)Astrocyte-Deri