Association of CCR2-CCR5 Haplotypes and CCL3L1 Copy Number with Kawasaki Disease, Coronary Artery Lesions, and IVIG Responses in Japanese Children 英文参考文献.docVIP
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Association of CCR2-CCR5 Haplotypes and CCL3L1 Copy Number with Kawasaki Disease, Coronary Artery Lesions, and IVIG Responses in Japanese Children 英文参考文献
AssociationofCCR2-CCR5HaplotypesandCCL3L1Copy
NumberwithKawasakiDisease,CoronaryArteryLesions,
andIVIGResponsesinJapaneseChildren
ManjuMamtani1,TomoyoMatsubara2,ChisatoShimizu3,SusumuFurukawa4,TeijiAkagi5 ,Yoshihiro
Onouchi6,AkiraHata7,AkihiroFujino8,WeijingHe1,SunilK.Ahuja1,9*,JaneC.Burns3
1SouthTexasVeteransHealthCareSystemandDepartmentofMedicine,TheVeteransAdministrationCenterforAIDSandHIV-1Infection,UniversityofTexasHealth
ScienceCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica,2DepartmentofPediatrics,JuntendoUniversityGraduateSchoolofMedicine,Chiba,Japan,
3DepartmentofPediatrics,RadyChildren’sHospital,UniversityofCaliforniaSanDiegoSchoolofMedicine,LaJolla,California,UnitedStatesofAmerica,4Departmentof
Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, 5Pediatrics Cardiac Care Unit, Okayama University Hospital, Okayama, Japan,
6Laboratory for Cardiovascular Diseases, Centerfor GenomicMedicine,RIKEN,Kanagawa, Japan, 7Department ofPublicHealth,ChibaUniversityGraduate School of
Medicine,Chiba,Japan,8DepartmentofSurgery,NationalCenterforChildHealthandDevelopment,Tokyo,Japan,9DepartmentsofMicrobiologyandImmunology,and
Biochemistry,UniversityofTexasHealthScienceCenter,SanAntonio,Texas,UnitedStatesofAmerica
Abstract
Background:TheetiologyofKawasakiDisease(KD)isenigmatic,althoughaninfectiouscauseissuspected.Polymorphisms
inCCchemokinereceptor5(CCR5)and/oritspotentligandCCL3L1influenceKDsusceptibilityinUS,EuropeanandKorean
populations.However,theinfluenceofthesevariationsonKDsusceptibility,coronaryarterylesions(CAL)andresponseto
intravenousimmunoglobulin(IVIG)inJapanesechildren,whohavethehighestincidenceofKD,isunknown.
Methodology/PrincipalFindings:Weusedunconditionallogisticregressionanalysestodeterminetheassociationsofthe
copynumberoftheCCL3L1gene-containingduplicationandCCR2-CCR5haplotypesin133JapaneseKDcases[33withCAL
and25withresistancetoIVIG]and312JapanesecontrolswithoutahistoryofKD.Weobservedthatthedeviationfromthe
populat
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