Assessment of Automated Disease Detection in Diabetic Retinopathy Screening Using Two-Field Photography 英文参考文献.docVIP
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Assessment of Automated Disease Detection in Diabetic Retinopathy Screening Using Two-Field Photography 英文参考文献
AssessmentofAutomatedDiseaseDetectioninDiabetic
RetinopathyScreeningUsingTwo-FieldPhotography
KeithGoatman1,AmandaCharnley2,LauraWebster2,StephenNussey2*
1SchoolofMedicineandDentistry,UniversityofAberdeen,Aberdeen,Scotland,2St.George’sHospital,London,UnitedKingdom
Abstract
Aim:Toassesstheperformanceofautomateddiseasedetectionindiabeticretinopathyscreeningusingtwofieldmydriatic
photography.
Methods:Imagesfrom8,271sequentialpatientscreeningepisodesfromaSouthLondondiabeticretinopathyscreening
service were processed by the Medalytix iGradingTM automated grading system. For each screening episode macular-
centredanddisc-centredimagesofbotheyeswereacquiredandindependentlygradedaccordingtotheEnglishnational
gradingscheme.Wherediscrepancieswerefoundbetweentheautomatedresultandoriginalmanualgrade,internaland
external arbitration was used to determine the final study grades. Two versions of the software were used: one that
detectedmicroaneurysmsalone,andonethatdetectedblothaemorrhagesandexudatesinadditiontomicroaneurysms.
Resultsforeachversionwerecalculatedonceusingbothfieldsandonceusingthemacula-centredfieldalone.
Results:Ofthe8,271episodes,346(4.2%)wereconsideredunassessable.Referablediseasewasdetectedin587episodes
(7.1%).Thesensitivityoftheautomatedsystemfordetectingunassessableimagesrangedfrom97.4%to99.1%depending
on configuration. The sensitivity of the automated system for referable episodes ranged from 98.3% to 99.3%. All the
episodesthatincludedproliferativeorpre-proliferativeretinopathyweredetectedbytheautomatedsystemregardlessof
configuration(192/192,95%confidenceinterval98.0%to100%).Ifimplementedasthefirststepingrading,theautomated
systemwouldhavereducedthemanualgradingeffortbybetween2,183and3,147patientepisodes(26.4%to38.1%).
Conclusion:Automatedgradingcansafelyreducetheworkloadofmanualgradingusingtwofield,mydriaticphotography
inaroutinescreeningservice.
Citation:GoatmanK,CharnleyA,WebsterL,NusseyS(2011)AssessmentofAutomatedDiseaseDetectioninDiabeticRetinopathyS
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