Ascaroside Expression in Caenorhabditis elegans Is Strongly Dependent on Diet and Developmental Stage 英文参考文献.docVIP
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Ascaroside Expression in Caenorhabditis elegans Is Strongly Dependent on Diet and Developmental Stage 英文参考文献
AscarosideExpressioninCaenorhabditiselegansIs
StronglyDependentonDietandDevelopmentalStage
FatmaKaplan1,JaganSrinivasan2,ParagMahanti3,RamadanAjredini4,OmerDurak2 ,Rathika
Nimalendran3,PaulW.Sternberg2,PeterE.A.Teal1,FrankC.Schroeder3,ArthurS.Edison4,HansT.
Alborn1*
1CenterforMedical,AgriculturalandVeterinaryEntomology,USDA-ARS,Gainesville,Florida,UnitedStatesofAmerica,2MedicalInstituteandBiologyDivision,California
Institute of Technology, Pasadena, California, United States of America, 3Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell
University, Ithaca, New York, United States of America, 4Department of Biochemistry and Molecular Biology, High Magnetic Field Laboratory, University of Florida,
Gainesville,Florida,UnitedStatesofAmerica
Abstract
Background: The ascarosides form a family of small molecules that have been isolated from cultures of the nematode
Caenorhabditiselegans.Theyareoftenreferredtoas‘‘dauerpheromones’’becausemostoftheminduceformationoflong-
livedandhighlystressresistantdauerlarvae.Morerecentstudieshaveshownthatascarosidesserveadditionalfunctionsas
socialsignalsandmatingpheromones.Thus,ascarosideshavemultiplefunctions.Untilnow,ithasbeengenerallyassumed
thatascarosidesareconstitutivelyexpressedduringnematodedevelopment.
Methodology/Principal Findings: Cultures of C. elegans were developmentally synchronized on controlled diets.
Ascarosides released into the media, as well as stored internally, were quantified by LC/MS. We found that ascaroside
biosynthesisandreleasewerestronglydependentondevelopmentalstageanddiet.Themaleattractingpheromonewas
verified to be a blend of at least four ascarosides, and peak production of the two most potent mating pheromone
components, ascr#3 and asc#8 immediately preceded or coincided with the temporal window for mating. The
concentration of ascr#2 increased under starvation conditions and peaked during dauer formation, strongly supporting
ascr#2 as the main population density signal
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