Arachidonic Acid Randomizes Endothelial Cell Motion and Regulates Adhesion and Migration 英文参考文献.docVIP
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Arachidonic Acid Randomizes Endothelial Cell Motion and Regulates Adhesion and Migration 英文参考文献
ArachidonicAcidRandomizesEndothelialCellMotion
andRegulatesAdhesionandMigration
NinnaStruckRossen1,AnkerJonHansen2,ChristineSelhuber-Unkel1,LeneBroengOddershede1*
1NielsBohrInstitute,UniversityofCopenhagen,Copenhagen,Denmark,2NovoNordiskA/S,Ma?l?v, Denmark
Abstract
Celladhesionandmigrationareessentialfortheevolution,organization,andrepairoflivingorganisms.Anexampleofa
combination of these processes is the formation of new blood vessels (angiogenesis), which is mediated by a directed
migrationandadhesionofendothelialcells(ECs).Angiogenesisisanessentialpartofwoundhealingandaprerequisiteof
canceroustumorgrowth.Weinvestigatedtheeffectoftheamphiphiliccompoundarachidonicacid(AA)onECadhesionand
migrationbycombininglivecellimagingwithbiophysicalanalysismethods.AAsignificantlyinfluencedbothECadhesionand
migration, in either a stimulating or inhibiting fashion depending on AA concentration. The temporal evolution of cell
adhesionareawaswelldescribedbyatwo-phasemodel.Inthefirstphase,thespreadingdynamicswereindependentofAA
concentration.Inthelatterphase,thespreadingdynamicsincreasedatlowAAconcentrationsanddecreasedathighAA
concentrations.AAalsoaffectedECmigration;thoughtheinstantaneousspeedofindividualcellsremainedindependentof
AAconcentration,theindividualcellslosttheirsenseofdirectionuponadditionofAA,thusgivingrisetoanoveralldecreasein
the collective motion of a confluent EC monolayer into vacant space. Addition of AA also caused ECs to become more
elongated,thispossiblybeingrelatedtoincorporationofAAintheECmembranethusmediatingachangeintheviscosityof
themembrane.Hence,AAisapromisingnon-receptorspecificregulatorofwoundhealingandangiogenesis.
Citation:RossenNS,HansenAJ,Selhuber-UnkelC,OddershedeLB(2011)ArachidonicAcidRandomizesEndothelialCellMotionandRegulatesAdhesionand
Migration.PLoSONE6(9):e25196.doi:10.1371/journal.pone.0025196
Editor:DanielJ.Muller,SwissFederalInstituteofTechnologyZurich,Switzerland
ReceivedMarch29,2011;AcceptedAugust30,2011;PublishedSeptember23,2
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