Apoptosis Induced by Piroxicam plus Cisplatin Combined Treatment Is Triggered by p21 in Mesothelioma 英文参考文献.docVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Apoptosis Induced by Piroxicam plus Cisplatin Combined Treatment Is Triggered by p21 in Mesothelioma 英文参考文献
ApoptosisInducedbyPiroxicamplusCisplatinCombined
TreatmentIsTriggeredbyp21inMesothelioma
AlfonsoBaldi1,MariaTeresaPiccolo2,MariaRosariaBoccellino1,AldoDonizetti2,IreneCardillo3,
RaffaeleLaPorta1,LucioQuagliuolo1,EnricoP.Spugnini3,FrancescaCordero5,GennaroCitro3 ,Massimo
Menegozzo4,RaffaeleA.Calogero5,StefaniaCrispi2*
1DepartmentofBiochemistry,SectionofPathology,SecondUniversityofNaples,Naples,Italy,2GeneExpressionHumanMolecularGeneticsLaboratory,Instituteof
GeneticsandBiophysics,CNR,Naples,Italy,3S.A.F.U.Department,ReginaElenaCancerInstitute,Rome,Italy,4CampaniaRegionalOperatingCenter(COR)oftheNational
MesotheliomaRegistry(ReNaM)-DepartmentofExperimentalMedicine,SecondUniversityofNaples,Naples,Italy,5BioinformaticsandGenomicsUnit,Departmentof
ClinicalandBiologicalScience,UniversityofTurin,Turin,Italy
Abstract
Background:Malignantmesothelioma(MM)isarare,highlyaggressivetumor,associatedtoasbestosexposure.Todateno
chemotherapy regimen for MM has proven to be definitively curative, and new therapies for MM treatment need to be
developed.Wehavepreviouslyshowninvivothatpiroxicam/cisplatincombinedtreatmentinMM,specificallyactsoncell
cycleregulationtriggeringapoptosis,withsurvivalincrease.
Methodology/Principal Findings: We analyzed, at molecular level, the apoptotic increase caused by piroxicam/cisplatin
treatmentinMMcelllines.Bymeansofgenomewideanalyses,weanalyzedtranscriptionalgenederegulationbothafter
thesinglepiroxicamorcisplatinandthecombinedtreatment.Hereweshowthatapoptoticincreasefollowingcombined
treatmentismediatedbyp21,sinceapoptoticincreaseinpiroxicam/cisplatincombinedtreatmentisabolisheduponp21
silencing.
Conclusions/Significance:Piroxicam/cisplatincombinedtreatmentdeterminesanapoptosisincreaseinMMcells,whichis
dependentonthep21expression.Theresultsprovidedsuggestthatpiroxicam/cisplatincombinationmightbetestedin
clinicalsettingsintumorspecimensthatexpressp21.
Citation:BaldiA,PiccoloMT,BoccellinoMR,DonizettiA,CardilloI,etal.(2011)ApoptosisInducedbyPiroxicamplu
您可能关注的文档
- Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells 英文参考文献.doc
- Antigen-Binding Properties of Monoclonal Antibodies Reactive with EBNA1 and Use in Immunoaffinity Chromatography 英文参考文献.doc
- Antigenic Characterization of Recombinant Hemagglutinin Proteins Derived from Different Avian Influenza Virus Subtypes 英文参考文献.doc
- Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets 英文参考文献.doc
- Antimicrobial Activity and Genetic Profile of Enteroccoci Isolated from Hoopoes Uropygial Gland 英文参考文献.doc
- Antifungal Activity of Resveratrol against Botrytis cinerea Is Improved Using 2-Furyl Derivatives 英文参考文献.doc
- Antihypertensive Treatment Differentially Affects Vascular Sphingolipid Biology in Spontaneously Hypertensive Rats 英文参考文献.doc
- Antimicrobial Activity of Human Prion Protein Is Mediated by Its N-Terminal Region 英文参考文献.doc
- Antimicrobial Resistance among Isolates Causing Invasive Pneumococcal Disease before and after Licensure of Heptavalent Conjugate Pneumococcal Vaccine 英文参考文献.doc
- Antimalarial Exposure Delays Plasmodium falciparum Intra-Erythrocytic Cycle and Drives Drug Transporter Genes Expression 英文参考文献.doc
文档评论(0)