Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation 英文参考文献.docVIP

下载本文档

4
0
约6.97万字
约 13页
2017-05-11 发布于上海
举报
版权申诉

Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation 英文参考文献.doc

1、本文档共13页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

ApoptosisofCD4CD25highTCellsinType1DiabetesMayBePartiallyMediatedbyIL-2Deprivation英文参考文献

ApoptosisofCD4+CD25high TCellsinType1Diabetes MayBePartiallyMediatedbyIL-2Deprivation ParthavJailwala1.,JillWaukau1.,SanjaGlisic1,SrikantaJana1,SarahEhlenbach1,MartinHessner1, RaminAlemzadeh2,ShigemiMatsuyama3,PurushottamLaud4,XujingWang5,SoumitraGhosh1* 1TheMaxMcGeeNationalResearchCenterforJuvenileDiabetesandTheHumanandMolecularGeneticsCenter,DepartmentofPediatricsattheMedicalCollegeof WisconsinandtheChildren’sResearchInstituteoftheChildren’sHospitalofWisconsin,Milwaukee,Wisconsin,UnitedStatesofAmerica,2Children’sHospitalofWisconsin DiabetesCenter,PediatricEndocrinologyandMetabolism,MedicalCollegeofWisconsin,Milwaukee,Wisconsin,UnitedStatesofAmerica,3DepartmentofPharmacology, CaseWesternReserveUniversity,Cleveland,Ohio,UnitedStatesofAmerica,4DivisionofBiostatistics,MedicalCollegeofWisconsin,Milwaukee,Wisconsin,UnitedStates ofAmerica,5DepartmentofPhysicstheComprehensiveDiabetesCenter,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStatesofAmerica Abstract Background:Type1diabetes(T1D)isaT-cellmediatedautoimmunediseasetargetingtheinsulin-producingpancreaticb + + cells. Naturally occurring FOXP3 CD4 CD25high regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing autoreactive CD4 effectorT cell activity. Previously, in both recent-onset T1D patients and bcell antibody- + positiveat-riskindividuals,weobservedincreasedapoptosisanddecreasedfunctionofpolyclonalTregsintheperiphery.Our objectiveherewastoelucidatethegenesandsignalingpathwaystriggeringapoptosisinTregs fromT1Dsubjects. Principal Findings: Gene expression profiles of unstimulated Tregs from recent-onset T1D (n=12) and healthy control subjects (n=15) were generated. Statistical analysis was performed using a Bayesian approach that is highly efficient in determiningdifferentiallyexpressedgeneswithlownumberofreplicatesamplesineachofthetwophenotypicgroups. Microarray analysis showed that several cytokine/chemokine receptor genes, HLA genes, GIMAP family genes and cell