Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice 英文参考文献.docVIP
- 1、本文档共12页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice 英文参考文献
AntioxidantTreatmentPromotesProstateEpithelial
ProliferationinNkx3.1MutantMice
ErinE.Martinez1,PhilipD.Anderson1,MonicaLogan2,SarkiA.Abdulkadir1,3*
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 2Department of
BiochemistryandCancerBiology,MeharryMedicalCollege,Nashville,Tennessee,UnitedStatesofAmerica,3DepartmentofCancerBiology,VanderbiltUniversityMedical
Center,Nashville,Tennessee,UnitedStatesofAmerica
Abstract
Discordantresultsinpreclinicalandclinicaltrialshaveraisedquestionsovertheeffectivenessofantioxidantsinprostate
cancerchemoprevention.Resultsfromthelarge-scaleSeleniumandVitaminECancerPreventionTrial(SELECT)showedthat
antioxidants failed to prevent, and in some cases promoted, prostate cancer formation in men without a history of the
disease.Onepossibleexplanationforthesealarmingresultsisthenotionthattheeffectsofantioxidanttreatmentonthe
prostate are modified by specific, intrinsic genetic risk factors, causing some men to respond negatively to antioxidant
treatment. Loss of expression of the homeobox transcription factor NKX3.1 in the prostate is frequently associated with
humanprostatecancer.Nkx3.1mutantmicedisplayprostatichyperplasiaanddysplasiaandareusedasamodeloftheearly
stagesofprostatecancerinitiation.WhilethemechanismsbywhichNkx3.1losspromotesprostatetumorigenicityarenot
completelyunderstood,publisheddatahavesuggestedthatelevatedreactiveoxygenspecies(ROS)associatedwithNkx3.1
lossmaybeacausativefactor.HerewehavetestedthishypothesisbytreatingNkx3.1mutantmicewiththeantioxidantN-
acetylcysteine(NAC)for13weekspost-weaning.Surprisingly,whileNACtreatmentdecreasedROSlevelsinNkx3.1mutant
mouseprostates,itfailedtoreduceprostaticepithelialhyperplasia/dysplasia.Rather,NACtreatmentincreasedepithelialcell
proliferation and promoted the expression of a pro-proliferative gene signature. These results show that ROS do not
promote proliferation intheNkx3.1-nullprostate, but
您可能关注的文档
- Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1 英文参考文献.doc
- Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI 英文参考文献.doc
- Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3KAkt and MEKERK Pathway 英文参考文献.doc
- Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule 英文参考文献.doc
- Anti-Prion Activity of Brilliant Blue G 英文参考文献.doc
- Anti-Nucleocapsid Protein Immune Responses Counteract Pathogenic Effects of Rift Valley Fever Virus Infection in Mice 英文参考文献.doc
- Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer 英文参考文献.doc
- Antibiotic Susceptibility Testing of Grown Blood Cultures by Combining Culture and Real-Time Polymerase Chain Reaction Is Rapid and Effective 英文参考文献.doc
- Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo 英文参考文献.doc
- Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses 英文参考文献.doc
文档评论(0)