Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma 英文参考文献.docVIP
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Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma 英文参考文献
AntineoplasticandApoptoticPotentialofTraditional
MedicinesThymoquinoneandDiosgenininSquamous
CellCarcinoma
SubhasisDas1,KaushikKumarDey1,GoutamDey1,IpsitaPal1,AbhijitMajumder2,
SujataMaitiChoudhury3,SubhasC.kundu4,MahitoshMandal1*
1SchoolofMedicalScienceandTechnology,IndianInstituteofTechnology-Kharagpur,WestBengal,India,2DepartmentofClinicalCancerPrevention,TheUniversityof
TexasMDAndersonCancerCenter,Houston,Texas,UnitedStatesofAmerica,3DepartmentofHumanPhysiologywithCommunityHealth,VidyasagarUniversity,West
Midnapur,WestBengal,India,4DepartmentofBiotechnology,IndianInstituteofTechnology-Kharagpur,WestBengal,India
Abstract
Thymoquinone(TQ)anddiosgenin(DG),theactiveingredientsobtainedfromblackcumin(Nigellasativa)andfenugreek
(Trigonellafoenumgraecum),respectively,exertpotentbioactivity,includinganticancereffects.Thisstudyinvestigatedthe
antineoplasticactivityoftheseagentsagainstsquamouscellcarcinomainvitroandsarcoma180–inducedtumorsinvivo.
TQandDGinhibitedcellproliferationandinducedcytotoxicityinA431andHep2cells.Theseagentsinducedapoptosisby
increasingthesub-G1population,LIVE/DEADcytotoxicity,chromatincondensation,DNAladderingandTUNEL-positivecells
significantly(P,0.05).IncreasedBax/Bcl-2ratio,activationofcaspasesandcleavageofpolyADPribosepolymerasewere
observed in treated cells. These drugs inhibited Akt and JNK phosphorylations, thus inhibiting cell proliferation while
inducingapoptosis.Incombination,TQandDGhadsynergisticeffects,resultingincellviabilityaslowas10%.Inamouse
xenograftmodel,acombinationofTQandDGsignificantly(P,0.05)reducedtumorvolume,massandincreasedapoptosis.
TQ and DG, alone and in combination, inhibit cell proliferation and induce apoptosis in squamous cell carcinoma. The
combinationofTQandDGisapotentialantineoplastictherapyinthiscommonskincancer.
Citation:DasS,DeyKK,DeyG,PalI,MajumderA,etal.(2012)AntineoplasticandApoptoticPotentialofTraditionalMedicinesThymoquinoneandDiosgeninin
SquamousCellCarcinoma.PLoSONE7(10):e46641.doi:10.1371/journal.pone.
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