Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State 英文参考文献.docVIP

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Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State 英文参考文献.doc

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Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State 英文参考文献

ArabidopsisthalianaChromosome4ReplicatesinTwo PhasesThatCorrelatewithChromatinState Tae-JinLee1.,PeteE.Pascuzzi2.,SharonB.Settlage2,RandallW.Shultz2¤a,MilosTanurdzic4,PabloD. Rabinowicz4¤b,MargitMenges5,PingZheng6,DorrieMain6,JamesA.H.Murray5,BryonSosinski1, GeorgeC.Allen1,RobertA.Martienssen4,LindaHanley-Bowdoin2,MatthewW.Vaughn4,WilliamF. Thompson3* 1Department of Horticultural Science, North Carolina State University, Raleigh, North Carolina, United States of America, 2Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina, United States of America, 3Departments of Plant Biology, Genetics, and Crop Science, North CarolinaStateUniversity,Raleigh,NorthCarolina,UnitedStatesofAmerica,4ColdSpringHarborLaboratory,ColdSpringHarbor,NewYork,UnitedStatesofAmerica, 5School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom, 6Department of Horticulture and Landscape Architecture, Washington State University, Pullman,Washington,UnitedStatesofAmerica Abstract DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications. Despite the conservation of core DNA replication proteins,littleisknownaboutreplicationprogramsinplants.WeusedflowcytometryandtilingmicroarraystoprofileDNA replicationofArabidopsisthalianachromosome4(chr4)duringearly,mid,andlateSphase.Replicationprofilesforearlyand midSphaseweresimilarandencompassedthemajorityoftheeuchromatin.LateSphaseexhibitedadistinctlydifferent profile that includes the remaining euchromatin and essentially all of the heterochromatin. Termination zones were consistentbetweenexperiments,allowingustodefine163putativerepliconsonchr4thatclusteredintolargerdomainsof predominately early or late replication. Early-replicating sequences, especially the initiation zones of early replicons, displayed a pattern of epigenetic modifications specifying an open chr