Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain 英文参考文献.docVIP

下载本文档

8
0
约2.82万字
约 6页
2017-05-11 发布于上海
举报
版权申诉

Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain 英文参考文献

Ascl1(Mash1)DefinesCellswithLong-TermNeurogenic PotentialinSubgranularandSubventricularZonesin AdultMouseBrain EuiseokJ.Kim1,JessicaL.Ables2,LaurenK.Dickel1,AmeliaJ.Eisch2,JaneE.Johnson1* 1DepartmentofNeuroscience,UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,UnitedStatesofAmerica,2DepartmentofPsychiatry,UniversityofTexas SouthwesternMedicalCenter,Dallas,Texas,UnitedStatesofAmerica Abstract Ascl1(Mash1)isabHLHtranscriptionfactoressentialforneuraldifferentiationduringembryogenesisbutitsroleinadult neurogenesisislessclear.HereweshowthatintheadultbrainAscl1isdynamicallyexpressedduringneurogenesisinthe dentategyrussubgranularzone(SGZ)andmorerostralsubventricularzone(SVZ).Specifically,wefindAscl1levelslowin SGZ Type-1 cells andSVZ B cells but increasing as thecells transition tointermediate progenitor stages. Invivo genetic lineage tracing with a tamoxifen (TAM) inducible Ascl1CreERT2 knock-in mouse strain shows that Ascl1 lineage cells continuously generate new neurons over extended periods of time. There is a regionally-specific difference in neuron generation,withmicegivenTAMatpostnatalday50showingnewdentategyrusneuronsthrough30dayspost-TAM,but showing new olfactory bulb neurons even 180 days post-TAM. These results show that Ascl1 is not restricted to transit amplifyingpopulationsbutisalsofoundinasubsetofneuralstemcellswithlong-termneurogenicpotentialintheadult brain. Citation: Kim EJ, Ables JL, Dickel LK, Eisch AJ, Johnson JE (2011) Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and SubventricularZonesinAdultMouseBrain.PLoSONE6(3):e18472.doi:10.1371/journal.pone.0018472 Editor:AlainChe′dotal,InstitutdelaVision,France ReceivedJanuary12,2011;AcceptedMarch2,2011;PublishedMarch31,2011 Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyonefor anylawfulpurpose.TheworkismadeavailableundertheCreativeCommonsCC0publicdomaindedication. Funding:Thiswork