Association of Body Mass and Brain Activation during Gastric Distention Implications for Obesity 英文参考文献.docVIP
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Association of Body Mass and Brain Activation during Gastric Distention Implications for Obesity 英文参考文献
AssociationofBodyMassandBrainActivationduring
GastricDistention:ImplicationsforObesity
DardoTomasi1*,Gene-JackWang2,3,RuiliangWang2,WalterBackus4,AllanGeliebter5,FrankTelang1,
MillarC.Jayne1,ChristopherWong1,JoannaS.Fowler2,3,NoraD.Volkow1,6
1NationalInstituteonAlcoholismandAlcoholAbuse,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica, 2MedicalDepartment,Brookhaven
NationalLaboratory,Upton,NewYork,UnitedStatesofAmerica,3DepartmentofPsychiatry,MtSinaiSchoolofMedicine,NewYork,NewYork,UnitedStatesofAmerica,
4Depertment of Anesthesiology, SUNY, Stony Brook, New York, United States of America, 5St. Luke’s/Roosevelt Hospital, Columbia University, New York, New York,
UnitedStatesofAmerica,6NationalInstituteonDrugAbuse,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica
Abstract
Background: Gastric distention (GD), as it occurs during meal ingestion, signals a full stomach and it is one of the key
mechanisms controlling food intake. Previous studies on GD showed lower activation of the amygdala for subjects with
higherbodymassindex(BMI).SinceobesesubjectshavedopaminergicdeficitsthatcorrelatenegativelywithBMIandthe
amygdalaisinnervatedbydopamineneurons,wehypothesizedthatBMIwouldcorrelatenegativelywithactivationnotjust
intheamygdalabutalsoinotherdopaminergicbrainregions(midbrainandhypothalamus).
Methodology/Principal Findings: We used functional magnetic resonance imaging (fMRI) to evaluate brain activation
duringGDin24healthysubjectswithBMIrangeof20–39kg/m2.Usingmultipleregressionandcross-correlationanalyses
basedonafamily-wiseerrorcorrectedthresholdP=0.05,weshowthatduringslowGDtomaximumvolumesof500mland
700ml subjects with increased BMI had increased activation in cerebellum and left posterior insula, and decreased
activation of dopaminergic (amygdala, midbrain, hypothalamus, thalamus) and serotonergic (pons) brain regions and
anteriorinsula,regionsthatwerefunctionallyinterconnectedwithoneanother.
Conclusions:Thenegativecorrelatio
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