Association of Blood Lead (Pb) and Plasma Homocysteine A Cross Sectional Survey in Karachi, Pakistan 英文参考文献.docVIP

AssociationofBloodLead(Pb)andPlasma Homocysteine:ACrossSectionalSurveyinKarachi, Pakistan MohsinYakub*,MohammadPerwaizIqbal DepartmentofBiologicalandBiomedicalSciences,AgaKhanUniversity,Karachi,Pakistan Abstract Background: High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemiainalowincomeurbanpopulationofKarachi,Pakistan. Methodology/PrincipalFindings:Inacrosssectionalsurvey,872healthyadults(355males,517females;age18–60years) wererecruitedfromalowincomeurbanpopulationofKarachi.Fastingvenousbloodwasobtainedandassessedforblood Pbandplasma/serumhomocysteine,folate,pyridoxalphosphate(PLP,acoenzymicformofvitaminB6)andvitaminB12. Thestudypopulationhadmedian(IQR)bloodPbof10.82mg/dL(8.29–13.60).PrevalenceofhighbloodPb(levels.10mg/ dL)washigherinmalescomparedtofemales(62.5%malesvs56%females;pvalue=0.05).Mean6SD/median(IQR)value of plasma homocysteine was significantly higher in the highest quartile of blood Pb compared to the lowest quartile 16.13611.2mmol/L vs 13.2869.7mmol/L/13.15 (10.33–17.81) mmol/L vs 11.09 (8.65 14.31) mmol/L (p value,0.001). Daily consumptionoffruitjuicehadapositiveinfluenceonbothlevelsofplasmahomocysteineandbloodPb.Comparedwith thelowestquartileofbloodPb,theORforhyperhomocysteinemiawas1.69(95%CI,1.00to2.85)forthefourthquartile whenthemodelwasadjustedforage,gender,folateandvitaminB12. Conclusions/Significance: This study showed a relationship between blood Pb and hyperhomocysteinemia in a general population of Karachi, Pakistan. The harmful effect of Pb on cardiovascular system could be due to its association with hyperhomocysteinemia. Citation: Yakub M, Iqbal MP (2010) Association of Blood Lead (Pb) and Plasma Homocysteine: A Cross Sectional Survey in Karachi, Pakistan.