Association of Activating KIR Copy Number Variation of NK Cells with Containment of SIV Replication in Rhesus Monkeys 英文参考文献.docVIP
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Association of Activating KIR Copy Number Variation of NK Cells with Containment of SIV Replication in Rhesus Monkeys 英文参考文献
AssociationofActivatingKIRCopyNumberVariationof
NKCellswithContainmentofSIVReplicationinRhesus
Monkeys
InaHellmann1,So-YonLim1,RebeccaS.Gelman2,NormanL.Letvin1*
1Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 2Department of
Biostatistics,DanaFarberCancerInstituteandHarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica
Abstract
WhilethecontributionofCD8+cytotoxicTlymphocytestoearlycontainmentofHIV-1spreadiswellestablished,arolefor
NKcellsincontrollingHIV-1replicationduringprimaryinfectionhasbeenuncertain.ThehighlypolymorphicfamilyofKIR
molecules expressed on NK cells can inhibit or activate these effector cells and might therefore modulate their activity
againstHIV-1-infectedcells.Inthepresentstudy,weinvestigatedcopynumbervariationinKIR3DHlociencodingtheonly
activatingKIRreceptorfamilyinrhesusmonkeysanditseffectonsimianimmunodeficiencyvirus(SIV)replicationduring
primaryinfectioninrhesusmonkeys.WeobservedanassociationbetweencopynumbersofKIR3DHgenesandcontrolof
SIVreplicationinMamu-A*01–rhesusmonkeysthatexpressrestrictiveTRIM5alleles.Thesefindingsprovidefurtherevidence
foranassociationbetweenNKcellsandtheearlycontainmentofSIVreplication,andunderscorethepotentialimportance
ofactivatingKIRsinstimulatingNKcellresponsestocontrolSIVspread.
Citation:HellmannI,LimS-Y,GelmanRS,LetvinNL(2011)AssociationofActivatingKIRCopyNumberVariationofNKCellswithContainmentofSIVReplication
inRhesusMonkeys.PLoSPathog7(12):e1002436.doi:10.1371/journal.ppat.1002436
Editor:GuidoSilvestri,EmoryUniversity,UnitedStatesofAmerica
ReceivedJuly5,2011;AcceptedOctober30,2011;PublishedDecember15,2011
Copyright: ? 2011 Hellmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding: This work was supported by the NI
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