Basic Helix-Loop-Helix Transcription Factor TCF21 Is a Downstream Target of the Male Sex Determining Gene SRY 英文参考文献.docVIP

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Basic Helix-Loop-Helix Transcription Factor TCF21 Is a Downstream Target of the Male Sex Determining Gene SRY 英文参考文献.doc

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Basic Helix-Loop-Helix Transcription Factor TCF21 Is a Downstream Target of the Male Sex Determining Gene SRY 英文参考文献

BasicHelix-Loop-HelixTranscriptionFactorTCF21Isa DownstreamTargetoftheMaleSexDeterminingGene SRY RamjiK.Bhandari,IngridSadler-Riggleman,TracyM.Clement,MichaelK.Skinner* CenterforReproductiveBiology,SchoolofBiologicalSciences,WashingtonStateUniversity,Pullman,Washington,UnitedStatesofAmerica Abstract ThecascadeofmoleculareventsinvolvedinmammaliansexdeterminationhasbeenshowntoinvolvetheSRYgene,but specific downstream events have eluded researchers for decades. The current study identifies one of the first direct downstreamtargetsofthemalesexdeterminingfactorSRYasthebasic-helix-loop-helix(bHLH)transcriptionfactorTCF21. SRYwasfoundtobindtotheTcf21promoterandactivategeneexpression.MutagenesisofSRY/SOX9responseelementsin theTcf21promotereliminatedtheactionsofSRY.SRYwasfoundtodirectlyassociatewiththeTcf21promoterSRY/SOX9 response elements in vivo during fetal rat testis development. TCF21 was found to promote an in vitro sex reversal of embryonicovariancellstoinduceprecursorSertolicelldifferentiation.TCF21andSRYhadsimilareffectsontheinvitrosex reversal gonadal cell transcriptomes. Therefore, SRY acts directly on the Tcf21 promoter to in part initiate a cascade of eventsassociatedwithSertolicelldifferentiationandembryonictestisdevelopment. Citation:BhandariRK,Sadler-RigglemanI,ClementTM,SkinnerMK(2011)BasicHelix-Loop-HelixTranscriptionFactorTCF21IsaDownstreamTargetoftheMale SexDeterminingGeneSRY.PLoSONE6(5):e19935.doi:10.1371/journal.pone.0019935 Editor:FerencMueller,UniversityofBirmingham,UnitedKingdom ReceivedDecember13,2010;AcceptedApril22,2011;PublishedMay17,2011 Copyright: ? 2011 Bhandari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisresearchwassupportedbyaNationalInstitutesofHealth(NIH)granttoMKS.Thefundershadnoroleinstudydesign,datacollectionandanalysis, decisiontopublish,or