Bayesian Comparison of Neurovascular Coupling Models Using EEG-fMRI 英文参考文献.docVIP

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Bayesian Comparison of Neurovascular Coupling Models Using EEG-fMRI 英文参考文献.doc

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Bayesian Comparison of Neurovascular Coupling Models Using EEG-fMRI 英文参考文献

BayesianComparisonofNeurovascularCouplingModels UsingEEG-fMRI MariaJ.Rosa*,JamesM.Kilner,WillD.Penny WellcomeTrustCentreforNeuroimaging,InstituteofNeurology,UniversityCollegeLondon,London,UnitedKindgom Abstract Functionalmagneticresonanceimaging(fMRI),withbloodoxygenationlevel-dependent(BOLD)contrast,isawidelyused technique for studying the human brain. However, it is an indirect measure of underlying neuronal activity and the processesthatlinkthisactivitytoBOLDsignalsarestillatopicofmuchdebate.InordertorelatefindingsfromfMRIresearch toothermeasuresofneuronalactivityitisvitaltounderstandtheunderlyingneurovascularcouplingmechanism.Currently, thereisnoconsensusontherelativerolesofsynapticandspikingactivityinthegenerationoftheBOLDresponse.Herewe designed a modelling framework to investigate different neurovascular coupling mechanisms. We use Electroencepha- lographic (EEG) and fMRI data from a visual stimulation task together with biophysically informed mathematical models describinghowneuronalactivitygeneratestheBOLDsignals.Thesemodelsallowustonon-invasivelyinferthedegreeof localsynapticandspikingactivityinthehealthyhumanbrain.Inaddition,weuseBayesianmodelcomparisontodecide betweenneurovascularcouplingmechanisms. WeshowthattheBOLD signalisdependentuponboththesynaptic and spikingactivitybutthattherelativecontributionsofthesetwoinputsaredependentupontheunderlyingneuronalfiring rate.WhentheunderlyingneuronalfiringislowthentheBOLDresponseisbestexplainedbysynapticactivity.However, whentheneuronalfiringrateishighthenbothsynapticandspikingactivityarerequiredtoexplaintheBOLDsignal. Citation: Rosa MJ, Kilner JM, Penny WD (2011) Bayesian Comparison of Neurovascular Coupling Models Using EEG-fMRI. PLoS Comput Biol 7(6): e1002070. doi:10.1371/journal.pcbi.1002070 Editor:ChristianBeckmann,UniversityofOxford,UnitedKingdom ReceivedOctober11,2010;AcceptedApril12,2011;PublishedJune16,2011 Copyright:?2011Rosaetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCo