Biological Consequences of Ancient Gene Acquisition and Duplication in the Large Genome of Candidatus Solibacter usitatus Ellin6076 英文参考文献.docVIP

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Biological Consequences of Ancient Gene Acquisition and Duplication in the Large Genome of Candidatus Solibacter usitatus Ellin6076 英文参考文献.doc

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Biological Consequences of Ancient Gene Acquisition and Duplication in the Large Genome of Candidatus Solibacter usitatus Ellin6076 英文参考文献

BiologicalConsequencesofAncientGeneAcquisition andDuplicationintheLargeGenomeofCandidatus SolibacterusitatusEllin6076 JeanF.Challacombe1*,StephanieA.Eichorst1,LorenHauser2,MiriamLand2,GaryXie1,CherylR.Kuske1 1BioscienceDivision,LosAlamosNationalLaboratory,LosAlamos,NewMexico,UnitedStatesofAmerica,2GenomeAnalysisandSystemsModelingGroup,Biosciences Division,OakRidgeNationalLaboratory,OakRidge,Tennessee,UnitedStatesofAmerica Abstract Members of the bacterial phylum Acidobacteria are widespread in soils and sediments worldwide, and are abundant in manysoils.Acidobacteriaarechallengingtocultureinvitro,andmanybasicfeaturesoftheirbiologyandfunctionalrolesin the soil have not been determined. Candidatus Solibacter usitatus strain Ellin6076 has a 9.9Mb genome that is approximately2–5timesaslargeastheothersequenced Acidobacteria genomes.Bacterialgenomesizestypically range from 0.5 to 10Mb and are influenced by gene duplication, horizontal gene transfer, gene loss and other evolutionary processes. Our comparative genome analyses indicate that the Ellin6076 large genome has arisen by horizontal gene transferviaancientbacteriophageand/orplasmid-mediatedtransduction,andwidespreadsmall-scalegeneduplications, resultinginanincreasednumberofparalogs.Lowaminoacidsequenceidentitiesamongfunctionalgroupmembers,and lackofconservedgeneorderandorientationinregionscontainingsimilargroupsofparalogs, suggestthatmostofthe paralogsarenottheresultofrecentduplicationevents.ThegenomesizesofadditionalculturedAcidobacteriastrainswere estimatedusingpulsed-fieldgelelectrophoresistodeterminetheprevalenceofthelargegenometraitwithinthephylum. Membersofsubdivision3hadlargergenomesthanthoseofsubdivision1,butnonewereaslargeastheEllin6076genome. The large genome of Ellin6076 may not be typical of the phylum, and encodes traits that could provide a selective metabolic,defensiveandregulatoryadvantageinthesoilenvironment. Citation:ChallacombeJF,EichorstSA,HauserL,LandM,XieG,etal.(2011)BiologicalCo