Biological Effects of Add-On Eicosapentaenoic Acid Supplementation in Diabetes Mellitus and Co-Morbid Depression A Randomized Controlled Trial 英文参考文献.docVIP

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Biological Effects of Add-On Eicosapentaenoic Acid Supplementation in Diabetes Mellitus and Co-Morbid Depression A Randomized Controlled Trial 英文参考文献.doc

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Biological Effects of Add-On Eicosapentaenoic Acid Supplementation in Diabetes Mellitus and Co-Morbid Depression A Randomized Controlled Trial 英文参考文献

BiologicalEffectsofAdd-OnEicosapentaenoicAcid SupplementationinDiabetesMellitusandCo-Morbid Depression:ARandomizedControlledTrial RoelJ.T.Mocking1*,JohannaAssies1,MariskaBot2,EugeneH.J.M.Jansen3,AartH.Schene1, Franc?oisPouwer2 1ProgramforMoodDisorders,DepartmentofPsychiatry,AmsterdamMedicalCenter,Amsterdam,TheNetherlands, 2CoRPS—CenterofResearchonPsychologyin Somaticdiseases,DepartmentofMedicalPsychologyandNeuropsychology,TilburgUniversity,Tilburg,TheNetherlands,3NationalInstituteforPublicHealthandthe Environment,LaboratoryforHealthProtectionResearch,Bilthoven,TheNetherlands Abstract Background:Eicosapentaenoicacid(EPA)mayreduceincreasedrisksfor(cardiovascular)morbidityandmortalityinpatients with diabetes mellitus (DM) and comorbid major depressive depression (MDD). Yet, effects of EPA-supplementation on biologicalriskfactorsforadverseoutcomeshavenotbeenstudiedinDM-patientswithMDD. Methods:Weperformedarandomized,double-blindtrial(n=25)comparingadd-onethyl-EPA-supplementationtoplacebo on(I)oxidativestress,(II)inflammatory,(III)hypothalamic-pituitary-adrenal(HPA)-axis,(IV)one-carbon-cycle,(V)fattyacid metabolismand(VI)lipoproteinparametersduring12-weeks’follow-up. Results:Besidesincreasesinsupplementeda-tocopherol[estimate(95%CI);3.62(1.14–6.11)mmol/l;p=0.006]andplasma anderythrocyteEPA,theinterventiondidnotinfluenceotheroxidativestress,inflammatoryorone-carbon-cycleparameters comparedtoplacebo.HPA-axisreactivitysignificantlydecreasedintheEPA-group(N=12)[AUCi:2121.93(2240.20–23.47) min6nmol/l; p=0.045], not in the placebo-group (N=12). Furthermore, EPA-supplementation increased erythrocyte and plasma docosapentaenoic acid, and decreased plasma arachidonic acid (AA) concentrations [21.61 (23.10–20.11) %; p=0.036].Finally,EPAhadamultivariateinfluenceonlipoproteinconcentrations(p=0.030),reflectedbyrelativeincreases inhighdensitylipoprotein[HDL;0.30(0.02–0.58)mmol/l;p=0.039]andtotalcholesterolconcentrations[1.01(0.29–1.72) mmol/l;p=0.008]. Conclusion:Overall,add-