Brain Activation in Response to Visceral Stimulation in Rats with Amygdala Implants of Corticosterone An fMRI Study 英文参考文献.docVIP

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Brain Activation in Response to Visceral Stimulation in Rats with Amygdala Implants of Corticosterone An fMRI Study 英文参考文献.doc

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Brain Activation in Response to Visceral Stimulation in Rats with Amygdala Implants of Corticosterone An fMRI Study 英文参考文献

BrainActivationinResponsetoVisceralStimulationin RatswithAmygdalaImplantsofCorticosterone:AnfMRI Study AnthonyC.Johnson2,BrentMyers2,JelenaLazovic3,RhealTowner4,BeverleyGreenwood-Van Meerveld1,2 * 1VAMedicalCenter,OklahomaCity,Oklahoma,UnitedStatesofAmerica,2OklahomaCenterforNeuroscience,UniversityofOklahomaHealthSciencesCenter,Oklahoma City, Oklahoma, United States of America, 3Biological Imaging Center, Division of Biology, California Institute of Technology, Pasadena, California, United States of America,4AdvancedMagneticResonanceCenter,OklahomaMedicalResearchFoundation,OklahomaCity,Oklahoma,UnitedStatesofAmerica Abstract Background: Althoughvisceral painofgastrointestinal (GI)originis themajor complaintin patientswithirritable bowel syndrome(IBS)itremainspoorlyunderstood.Brainimagingstudiessuggestadefectinbrain-gutcommunicationinIBSwith agreateractivationofcentralarousalcircuitsincludingtheamygdala.Previously,wefoundthatstereotaxicimplantationof corticosterone(CORT)ontotheamygdalainratsinducedanxietyandcolonichypersensitivity.Inthepresentstudyweused functional magnetic resonance imaging (fMRI) to identify specific brain sites activated in a rat model characterized by anxietyandcolonichypersensitivity. Methodology/PrincipalFindings:Anesthetizedmaleratsreceivedmicropellets(30mgeach)ofeitherCORTorcholesterol (CHOL),toserveasacontrol,implantedstereotaxicallyonthedorsalmarginofeachamygdala.Sevendayslater,ratswere anesthetizedandplacedinthefMRImagnet(7T).Aseriesofisobariccolorectalballoondistensions(CRD-90s‘off’,30s‘on’, 8replicates)attwopressures(40and60mmHg)wereperformedinastandardblock-design.Crosscorrelationstatistical analysiswas usedtodeterminesignificant differencesbetweendistended andnon-distendedstates inCORT andCHOL- treatedanimals.AnalysisoftheimagingdatademonstratedgreateroverallbrainactivationinresponsetoCRDinratswith CORTimplantscomparedtoCHOLcontrols.Additionally,CORTimplantsproducedsignificantpositivebilateralincreasesin MRIsignalinresponsetoCRDin