Can Linear Regression Modeling Help Clinicians in the Interpretation of Genotypic Resistance Data An Application to Derive a Lopinavir-Score 英文参考文献.docVIP

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Can Linear Regression Modeling Help Clinicians in the Interpretation of Genotypic Resistance Data An Application to Derive a Lopinavir-Score 英文参考文献.doc

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Can Linear Regression Modeling Help Clinicians in the Interpretation of Genotypic Resistance Data An Application to Derive a Lopinavir-Score 英文参考文献

CanLinearRegressionModelingHelpCliniciansinthe InterpretationofGenotypicResistanceData?An ApplicationtoDeriveaLopinavir-Score AlessandroCozzi-Lepri1,2*,MattiaC.F.Prosperi3,JesperKj?r4,DavidDunn5,RogerParedes6,CarolineA. Sabin1,JensD.Lundgren4,7,AndrewN.Phillips1,DeenanPillay8,fortheEuroSIDAandtheUnited KingdomCHIC/UnitedKingdomHDRDStudies 1Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, London, United Kingdom, 2Division of Biostatistics,UniversityofMinnesota,Minneapolis,Minnesota,UnitedStatesofAmerica,3DepartmentofPathology,ImmunologyandLaboratoryMedicine,Emerging PathogensInstitute,CollegeofMedicine,UniversityofFlorida,Gainesville,Florida,UnitedStatesofAmerica,4CopenhagenHIVProgramme,UniversityofCopenhagen, PanumInstitute,Copenhagen, Denmark,5MedicalResearchCouncilClinicalTrialsUnit,London,UnitedKingdom,6HIVUnitandirsiCaixaRetrovirologyLab,Hospital UniversitariGermansTriasiPujol,Barcelona,Spain,7CentreforViralDisease,DepartmentofInfectiousDiseases,CopenhagenUniversityHospital,Copenhagen,Denmark, 8DepartmentofVirology,UniversityCollegeLondon,London,UnitedKingdom Abstract Background: The question of whether a score for a specific antiretroviral (e.g. lopinavir/r in this analysis) that improves predictionofviralloadresponsegivenbyexistingexpert-basedinterpretationsystems(IS)couldbederivedfromanalyzing thecorrelationbetweengenotypicdataandvirologicalresponseusingstatisticalmethodsremainslargelyunanswered. MethodsandFindings:WeusedthedataofthepatientsfromtheUKCollaborativeHIVCohort(UKCHIC)Studyforwhom genotypicdatawerestoredintheUKHIVDrugResistanceDatabase(UKHDRD)toconstructatraining/validationdatasetof treatmentchangeepisodes(TCE).Weusedtheaveragesquareerror(ASE)ona10-foldcross-validationandonatestdataset (the EuroSIDA TCE database) to compare the performance of a newly derived lopinavir/r score with that of the 3 most widelyusedexpert-basedinterpretationrules(ANRS,HIVDBandRega).Ouranalysisidentifi