Casein Kinase 1 Delta (CK1δ) Regulates Period Length of the Mouse Suprachiasmatic Circadian Clock In Vitro 英文参考文献.docVIP

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Casein Kinase 1 Delta (CK1δ) Regulates Period Length of the Mouse Suprachiasmatic Circadian Clock In Vitro 英文参考文献.doc

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Casein Kinase 1 Delta (CK1δ) Regulates Period Length of the Mouse Suprachiasmatic Circadian Clock In Vitro 英文参考文献

CaseinKinase1Delta(CK1d)RegulatesPeriodLengthof theMouseSuprachiasmaticCircadianClockInVitro Jean-PierreEtchegaray1,ElizabethA.Yu1,PremanandaIndic2,RobertDallmann1¤,DavidR.Weaver1* 1DepartmentofNeurobiology,UniversityofMassachusettsMedicalSchool,Worcester,Massachusetts,UnitedStatesofAmerica,2DepartmentofNeurology,Universityof MassachusettsMedicalSchool,Worcester,Massachusetts,UnitedStatesofAmerica Abstract Background:Caseinkinase1delta(CK1d)playsamoreprominentroleintheregulationofcircadiancyclelengththanits homologuecaseinkinase1epsilon(CK1e)inperipheraltissuessuchasliverandembryonicfibroblasts.MicelackingCK1d dieshortlyafterbirth,soithasnotbeenpossibletoassesstheimpactoflossofCK1donbehavioralrhythmscontrolledby themastercircadianoscillatorinthesuprachiasmaticnuclei(SCN). Methodology/Principal Findings: In the present study, mPER2::LUCIFERASE bioluminescence rhythms were monitored fromSCN explantscollected fromneonatalmice. Thedata demonstratethatSCN explantsfrom neonatalCK1d-deficient mice oscillate, but with a longer circadian period than littermate controls. The cycle length of rhythms recorded from neonatalSCNexplantsofCK1e-deficientmicedidnotdifferfromcontrolexplants. Conclusions/Significance:TheresultsindicatethatCK1dplaysamoreprominentrolethanCK1einthemaintenanceof24- hourrhythmsinthemastercircadianoscillator. Citation: EtchegarayJ-P,YuEA,IndicP,DallmannR,WeaverDR(2010)CaseinKinase1Delta(CK1d)RegulatesPeriodLengthoftheMouseSuprachiasmatic CircadianClockInVitro.PLoSONE5(4):e10303.doi:10.1371/journal.pone.0010303 Editor:ShinYamazaki,VanderbiltUniversity,UnitedStatesofAmerica ReceivedFebruary28,2010;AcceptedApril1,2010;PublishedApril22,2010 Copyright: ?2010Etchegarayetal.Thisisanopen-access article distributedundertheterms oftheCreative CommonsAttributionLicense,which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyNationalInstitutesofHealthAwardR01NS056125fro