CD8+ T-Cell Interleukin-7 Receptor Alpha Expression as a Potential Indicator of Disease Status in HIV-Infected Children 英文参考文献.docVIP

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CD8+ T-Cell Interleukin-7 Receptor Alpha Expression as a Potential Indicator of Disease Status in HIV-Infected Children 英文参考文献.doc

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CD8T-CellInterleukin-7ReceptorAlphaExpressionasaPotentialIndicatorofDiseaseStatusinHIV-InfectedChildren英文参考文献

CD8+T-CellInterleukin-7ReceptorAlphaExpressionasa PotentialIndicatorofDiseaseStatusinHIV-Infected Children TanviS.Sharma1,JaneHughes2,AmarylisMurillo3,JoanneRiley2,AndreiaSoares2,FrancescaLittle4, CharlesD.Mitchell3,WillemA.Hanekom2* 1Division of Pediatric Infectious Diseases, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America, 2South African Tuberculosis VaccineInitiative,School ofChildandAdolescentHealth,CapeTown,South Africa, 3DivisionofPediatricInfectiousDiseases, MillerSchool ofMedicine, UniversityofMiami,Miami,Florida,UnitedStatesofAmerica,4DepartmentofStatisticalSciences,UniversityofCapeTown,CapeTown,SouthAfrica Abstract Background:InitiationandmodificationofantiretroviraltherapyinHIV-infectedchildrendependonviralloadandCD4+T- cellcount.However,thesesurrogateshavelimitations,andcomplementaryimmunologicalmarkerstoassesstherapeutic responseareneeded.OuraimwastoevaluateCD8+T-cellexpressionofCD127asamarkerofdiseasestatusinHIV-infected children,basedonadultdatasuggestingitsusefulness.WehypothesizedthatCD127expressiononCD8+T-cellsislowerin childrenwithmoreadvanceddisease. Methods:Inacross-sectionalevaluation,weusedflowcytometrytomeasureCD127+expressiononCD8+T-cellsinwhole bloodfromHIV-infectedchildrenwithvaryingdiseasestatus.ThiswascomparedwithexpressionofCD38onthissubset, currentlyusedinclinicalpracticeasamarkerofdiseasestatus. Results:51HIV-infectedchildrenwereenrolled.TherewasastrongpositivecorrelationbetweenCD127expressiononCD8+ T-cellsandCD4+T-cellcount,andheightandweightz-scores,andastrongnegativecorrelationbetweenCD127expression andviralload.Incontrast,wefoundnoassociationbetweenCD38expressionandthesediseasestatusmarkers. Conclusions:CD8+T-cellCD127expressionissignificantlyhigherinchildrenwithbetterHIVdiseasecontrol,andmayhave aroleasanimmunologicindicatorofdiseasestatus.Longitudinalstudiesareneededtodeterminetheutilityofthismarker asapotentialindicatorofHIVdiseaseprogression. Citation:SharmaTS,HughesJ