Cell-Type Specific Roles for PTEN in Establishing a Functional Retinal Architecture 英文参考文献.docVIP

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Cell-Type Specific Roles for PTEN in Establishing a Functional Retinal Architecture 英文参考文献.doc

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Cell-Type Specific Roles for PTEN in Establishing a Functional Retinal Architecture 英文参考文献

Cell-TypeSpecificRolesforPTENinEstablishinga FunctionalRetinalArchitecture RobertCantrup1,RajivDixit1,ElenaPalmesino2,StephanBonfield3,TarekShaker1 ,Nobuhiko Tachibana1,DawnZinyk1,SarahDalesman5,KazuhiroYamakawa6,WilliamK.Stell3,RachelO.Wong7, BenjaminE.Reese4,ArturKania2,YvesSauve′8,CarolSchuurmans1* 1Department of Biochemistry and Molecular Biology, Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada,2DepartmentofMedicine,InstitutdeRecherchesCliniquesdeMontre′al(IRCM),Universite′deMontre′al,Montre′al,Quebec,Canada,3DepartmentofCellBiology andAnatomy,HotchkissBrainInstitute,AlbertaChildren’sHospitalResearchInstitute,UniversityofCalgary,Calgary,Alberta,Canada,4DepartmentofPsychologicaland BrainSciences,NeuroscienceResearchInstitute,UniversityofCaliforniaSantaBarbara,SantaBarbara,California,UnitedStatesofAmerica,5DepartmentofPhysiologyand Pharmacology, Hotchkiss Brain Institute,Alberta Children’s Hospital Research Institute, University ofCalgary, Calgary, Alberta, Canada, 6Laboratory of Neurogenetics, RIKENBrainScienceInstitute,Wako-shi,Saitama,Japan,7DepartmentofBiologicalStructure,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica, 8DepartmentofOphthalmology,UniversityofAlberta,Edmonton,Alberta,Canada Abstract Background:Theretinahasauniquethree-dimensionalarchitecture,thepreciseorganizationofwhichallowsforcomplete samplingofthevisualfield.Alongtheradialorapicobasalaxis,retinalneuronsandtheirdendriticandaxonalarborsare segregated into layers, while perpendicular to this axis, in the tangential plane, four of the six neuronal types form patterned cellular arrays, or mosaics. Currently, the molecular cues that control retinal cell positioning are not well- understood,especiallythosethatoperateinthetangentialplane.HereweinvestigatedtheroleofthePTENphosphatasein establishingafunctionalretinalarchitecture. Methodology/Principal Findings: In the developing retina, PTEN was localized pre