CdSe Quantum Dot (QD)-Induced Morphological and Functional Impairments to Liver in Mice 英文参考文献.docVIP

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CdSe Quantum Dot (QD)-Induced Morphological and Functional Impairments to Liver in Mice 英文参考文献.doc

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CdSe Quantum Dot (QD)-Induced Morphological and Functional Impairments to Liver in Mice 英文参考文献

CdSeQuantumDot(QD)-InducedMorphologicaland FunctionalImpairmentstoLiverinMice WeiLiu1,2,ShupingZhang1,LixinWang1,ChenQu1,ChangwenZhang1,LeiHong1,LinYuan1 ,Zehao Huang1,ZheWang1,SijinLiu1*,GuibinJiang1 1StateKeyLaboratoryofEnvironmentalChemistryandEcotoxicology,ResearchCenterforEco-Environmental Sciences, ChineseAcademyofSciences, Beijing, China, 2DepartmentofMicrobiology,ComprehensiveCancerCenter,UniversityofPennsylvaniaMedicalSchool,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract Quantumdots(QDs),asuniquenanoparticleprobes,havebeenusedininvivofluorescenceimagingsuchascancers.Due tothenovelcharacteristicsinfluorescence,QDsrepresentafamilyofpromisingsubstancestobeusedinexperimentaland clinicalimaging.Thusfar,thetoxicityandharmfulhealtheffectsfromexposure(includingenvironmentalexposure)toQDs arenotrecognized,butarelargelyconcernedbythepublic.ToassessthebiologicaleffectsofQDs,weestablishedamouse model of acute and chronic exposure to QDs. Results from the present study suggested that QD particles could readily spreadintovariousorgans,andliverwasthemajororganforQDaccumulationinmicefromboththeacuteandchronic exposure.QDscausedsignificantimpairmentstoliversfrommicewithbothacuteandchronicQDexposureasreflectedby morphological alternation to the hepatic lobules and increased oxidative stress. Moreover, QDs remarkably induced the productionofintracellularreactiveoxygenspecies(ROS)alongwithcytotoxicity,ascharacterizedbyasignificantincreaseof themalondialdehyde(MDA)levelwithinhepatocytes.However,theincreaseoftheMDAlevelinresponsetoQDtreatment could be partially blunted by the pre-treatment of cells with beta-mercaptoethanol (b-ME). These data suggested ROS played a crucial role in causing oxidative stress-associated cellular damage from QD exposure; nevertheless other unidentifiedmediatorsmightalsobeinvolvedinQD-mediatedcellularimpairments.Importantly,wedemonstratedthatthe hepatoxicitycausedbyQDsinvivoandinvitrowasmuchgreaterthanthatinducedbycadmiumionsatasimi