Differential Expression of Phospholipase C Epsilon 1 Is Associated with Chronic Atrophic Gastritis and Gastric Cancer 英文参考文献.docVIP

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Differential Expression of Phospholipase C Epsilon 1 Is Associated with Chronic Atrophic Gastritis and Gastric Cancer 英文参考文献.doc

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Differential Expression of Phospholipase C Epsilon 1 Is Associated with Chronic Atrophic Gastritis and Gastric Cancer 英文参考文献

DifferentialExpressionofPhospholipaseCEpsilon1Is AssociatedwithChronicAtrophicGastritisandGastric Cancer JunChen1,WeiWang2,3,TaoZhang4,JiajiaJi1,QirongQian5,LungengLu6,HualinFu1,WeilinJin1,7, DaxiangCui1* 1DepartmentofBio-NanoScienceandEngineering,KeyLabofThinFilmandMicrofabricationTechnologyofDepartmentofEducation,InstituteofMicro/NanoScience andTechnology,ShanghaiJiaoTongUniversity,Shanghai,People’sRepublicofChina,2StateKeyLaboratoryofOncologyinSouthChina,SunYat-senUniversityCancer Center, Guangzhou, Guangdong, People’s Republic of China, 3Department of Gastric Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong,People’sRepublicofChina,4DepartmentofImmunology,FujianAcademyofMedicalScience,Fuzhou,People’sRepublicofChina,5DepartmentofSurgery, ChangzhengHospitalaffiliatedtoSecondMilitaryMedicalUniversity,Shanghai,People’sRepublicofChina,6InstituteofDigestiveDisease,TheFirstAffiliatedHospitalof Shanghai Jiao Tong University, Shanghai, People’s Republic ofChina, 7School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People’s RepublicofChina Abstract Background:Chronicinflammationplaysacausalroleingastrictumorinitiation.Theidentificationofpredictivebiomarkers fromgastricinflammationtotumorigenesiswillhelpustodistinguishgastriccancerfromatrophicgastritisandestablish thediagnosisofearly-stagegastriccancer.PhospholipaseCepsilon1(PLCe1)isreportedtoplayavitalroleininflammation andtumorigenesis.ThisstudywasaimedtoinvestigatetheclinicalsignificanceofPLCe1intheinitiationandprogressionof gastriccancer. Methodology/Principal Findings: Firstly, the mRNA and protein expression of PLCe1 were analyzed by reverse transcription-PCR and Western blotting in normal gastric mucous epithelial cell line GES-1 and gastric cancer cell lines AGS, SGC7901, and MGC803. The results showed both mRNA and protein levels of PLCe1 were up-regulated in gastric cancer cells compared with normal gastric mucous epithelial cells. Secondly, this