Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes 英文参考文献.docVIP

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Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes 英文参考文献.doc

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Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes 英文参考文献

Dll1HaploinsufficiencyinAdultMiceLeadstoaComplex PhenotypeAffectingMetabolicandImmunological Processes IsabelRubio-Aliaga1¤,GerhardK.H.Przemeck1,HelmutFuchs1,Vale′rieGailus-Durner1,ThureAdler1,2, WolfgangHans1,MarionHorsch1,BirgitRathkolb1,3,JanRozman1,4,AnjaSchrewe1,5,SibylleWagner1, SabineM.Hoelter6,LoreBecker1,7,ThomasKlopstock7,WolfgangWurst6,9,EckhardWolf3 ,Martin Klingenspor4,BorisT.Ivandic5,DirkH.Busch2,JohannesBeckers1,8*,MartinHrabe′ deAngelis1,8 * 1Institute ofExperimental Genetics,HelmholtzZentrumMuenchen, GermanResearchCenter forEnvironmentalHealth,Neuherberg,Germany, 2Institute forMedical Microbiology,ImmunologyandHygiene,TechnischeUniversitaetMuenchen,Munich,Germany,3ChairforMolecularAnimalBreedingandBiotechnology/LAFUGA,Gene Center, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany, 4Molecular Nutritional Medicine, Technische Universitaet Muenchen, Else Kroener-Fresenius Center, Freising-Weihenstephan, Germany, 5Department of Medicine III, Division of Cardiology, University of Heidelberg, Heidelberg, Germany, 6Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany, 7Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-Universitaet, Munich, Germany, 8Lehrstuhl fuer Experimentelle Genetik, Technische Universitaet Muenchen, Freising- Weihenstephan,Germany,9LehrstuhlfuerEntwicklungsgenetik,TechnischeUniversitaetMuenchen,Freising-Weihenstephan,Germany Abstract Background:TheNotchsignalingpathwayisanevolutionaryconservedsignaltransductionpathwayinvolvedinembryonic patterningandregulationofcellfatesduringdevelopmentandself-renewal.Recentstudieshavedemonstratedthatthis pathway is integral to a complex system of interactions, involving as well other signal transduction pathways, and implicatedindistincthumandiseases.Delta-like1(Dll1)isoneoftheknownligandsoftheNotchreceptors.Theroleofthe Notch ligands is less well understood. Loss-of-function of