Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-Independent Mechanism 英文参考文献.docVIP

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Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-Independent Mechanism 英文参考文献.doc

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Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-Independent Mechanism 英文参考文献

DrosophilaLipophorinReceptorsMediatetheUptakeof NeutralLipidsinOocytesandImaginalDiscCellsbyan Endocytosis-IndependentMechanism EsmeraldaParra-Peralbo,JoaquimCuli* CentroAndaluzdeBiolog?′adelDesarrollo(CSIC-UPO),UniversidadPablodeOlavide,Sevilla,Spain Abstract Lipids are constantly shuttled through the body to redistribute energy and metabolites between sites of absorption, storage, and catabolism in a complex homeostatic equilibrium. In Drosophila, lipids are transported through the hemolymph in the form of lipoprotein particles, known as lipophorins. The mechanisms by which cells interact with circulatinglipophorinsandacquiretheirlipidiccargoarepoorlyunderstood.Wehavefoundthatlipophorinreceptor1and2 (lpr1 and lpr2), two partially redundant genes belonging to the Low Density Lipoprotein Receptor (LDLR) family, are essential for the efficient uptake and accumulation of neutral lipids by oocytes and cells of the imaginal discs. Females lackingthelpr2genelayeggswithlowlipidcontentandhavereducedfertility,revealingacentralroleforlpr2inmediating Drosophilavitellogenesis.lpr1andlpr2aretranscribedintomultipleisoforms.Interestingly,onlyasubsetoftheseisoforms containing a particular LDLR type A module mediate neutral lipid uptake. Expression of these isoforms induces the extracellularstabilizationoflipophorins.Furthermore,ourdataindicatethatendocytosisofthelipophorinreceptorsisnot requiredtomediatetheuptakeofneutrallipids.Thesefindingssuggestamodelwherelipophorinreceptorspromotethe extracellularlipolysisoflipophorins.Thismodelisreminiscentofthelipolyticprocessingoftriglyceride-richlipoproteinsthat occursatthemammaliancapillaryendothelium,suggestinganancientroleforLDLR–likeproteinsinthisprocess. Citation: Parra-Peralbo E, Culi J (2011) Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-IndependentMechanism.PLoSGenet7(2):e1001297.doi:10.1371/journal.pgen.1001297 Editor:KavehAshrafi,UniversityofCaliforniaS