Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone 英文参考文献.docVIP

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Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone 英文参考文献.doc

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Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone 英文参考文献

DrosophilaRibosomalProteinMutantsControlTissue GrowthNon-AutonomouslyviaEffectsonthe ProthoracicGlandandEcdysone JaneI.Lin1,2,NaomiC.Mitchell3,MarinaKalcina3,EllyTchoubrieva1,MaryJ.Stewart4¤,StevenJ. Marygold5,CherrylD.Walker5,GeorgeThomas6,SallyJ.Leevers5,RichardB.Pearson1,2,7.,LeonieM. Quinn3.*,RossD.Hannan1,2,7,8. * 1Peter MacCallum Cancer Centre, East Melbourne, Australia, 2Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Australia, 3DepartmentofAnatomyandCellBiology,UniversityofMelbourne,Parkville,Australia,4DepartmentofBiologicalSciences,NorthDakotaStateUniversity,Fargo,North Dakota,UnitedStatesofAmerica,5GrowthRegulationLaboratory,CancerResearchUKLondonResearchInstitute,London,UnitedKingdom,6UniversityofCincinnati MedicalCenter,Cincinnati,Ohio,UnitedStatesofAmerica,7DepartmentofBiochemistryandCellBiology,MonashUniversity,Clayton,Australia,8SchoolofBiomedical Sciences,TheUniversityofQueensland,Brisbane,Australia Abstract The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomalproteins(Rps)actastumoursuppressorsinDrosophilaandvertebrates.ToexaminehowreductionsinRpscould leadtotissueovergrowth,wetookadvantageoftheobservationthatan RpS6 mutantdominantly suppresses thesmall rougheyephenotypeinacyclinEhypomorphicmutant(cycEJP).WedemonstratedthatthesuppressionofcycEJP bythe RpS6mutantisnotaconsequenceofrestoringCycEproteinlevelsoractivityintheeyeimaginaltissue.Rather,theuseof UAS-RpS6RNAitransgenicsrevealedthatthesuppressionofcycEJPisexertedviaamechanismextrinsictotheeye,whereby reducedRplevelsintheprothoracicglanddecreasestheactivityofecdysone,thesteroidhormone,delayingdevelopmental timingandhenceallowingtimefortissueandorganovergrowth.Thesedataprovideforthefirsttimearationaletoexplain the counter-intuitive organ overgrowth phenotypes observed for certain members of the Minute class of Drosophila Rp mutants.TheyalsodemonstratehowRpmutan