Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES 英文参考文献.docVIP

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Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES 英文参考文献.doc

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Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES 英文参考文献

DualEnergyX-RayAbsorptiometryBodyComposition ReferenceValuesfromNHANES ThomasL.Kelly1*,KevinE.Wilson1,StevenB.Heymsfield2 1Hologic,Inc.,Bedford,Massachusetts,UnitedStatesofAmerica,2MerckCo.,Rahway,NewJersey,UnitedStatesofAmerica Abstract In2008theNationalCenterforHealthStatisticsreleasedadualenergyx-rayabsorptiometry(DXA)wholebodydatasetfrom theNHANESpopulation-basedsampleacquiredwithmodernfanbeamscannersin15countiesacrosstheUnitedStates from1999through2004.TheNHANESdatasetwaspartitionedbygenderandethnicityandDXAwholebodymeasuresof %fat,fatmass/height2,leanmass/height2,appendicularleanmass/height2,%fattrunk/%fatlegsratio,trunk/limbfatmass ratio offat, bone mineral content (BMC) andbone mineral density (BMD) wereanalyzed to provide reference values for subjects8to85yearsold.DXAreferencevaluesforadultswerenormalizedtoage;referencevaluesforchildrenincluded total and sub-total whole body results and were normalized to age, height, or lean mass. We developed an obesity classification scheme by using estabbody mass index (BMI) classification thresholds and prevalences in young adults to generatematching classification thresholds for FatMass Index (FMI; fat mass/height2). Thesereference values should be helpfulintheevaluationofavarietyofadultandchildhoodabnormalitiesinvolvingfat,lean,andbone,forestablishing entrycriteriaintoclinicaltrials,andforothermedical,research,andepidemiologicaluses. Citation:KellyTL,WilsonKE,HeymsfieldSB(2009)DualEnergyX-RayAbsorptiometryBodyCompositionReferenceValuesfromNHANES.PLoSONE4(9):e7038. doi:10.1371/journal.pone.0007038 Editor:AdrianVella,MayoClinicCollegeofMedicine,UnitedStatesofAmerica ReceivedApril16,2009;AcceptedJuly31,2009;PublishedSeptember15,2009 Copyright:?2009Kellyetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:TheNationalHealthandNutritionSurvey(NHANES)designedthe