Earlier Mothers Age at Menarche Predicts Rapid Infancy Growth and Childhood Obesity 英文参考文献.docVIP

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Earlier Mothers Age at Menarche Predicts Rapid Infancy Growth and Childhood Obesity 英文参考文献.doc

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Earlier Mothers Age at Menarche Predicts Rapid Infancy Growth and Childhood Obesity 英文参考文献

o PL SMEDICINE EarlierMother’sAgeatMenarchePredicts RapidInfancyGrowthandChildhoodObesity Ken KOng1,2*,Kate Northstone3,Jonathan CK Wells4,Carol Rubin5,Andy RNess3,Jean Golding6,David BDunger2 1 Medical Research Council Epidemiology Unit, Cambridge, United Kingdom, 2 Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom, 3 Department of Social Medicine, University of Bristol, United Kingdom, 4 Childhood Nutrition Research Centre, Institute of Child Health, London, United Kingdom, 5NationalCenterforEnvironmentalHealth,CentersforDiseaseControlandPrevention,Atlanta,UnitedStatesofAmerica,6DepartmentofCommunityBasedMedicine, UniversityofBristol,UnitedKingdom Funding:Thisresearchwas ABSTRACT specificallyfundedbytheCenters forDiseaseControlandPrevention, UnitedStatesofAmerica.The fundershadnoroleinstudydesign, datacollectionandanalysis,decision topublish,orpreparationofthe manuscript. Background Earlymenarche tends tobe preceded byrapid infancy weightgain and is associatedwith increased childhood and adult obesity risk. As age at menarche is a heritable trait, we hypothesised that age at menarche in the mother may in turn predict her children’s early growthandobesityrisk. CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. MethodsandFindings AcademicEditor:AndrewPrentice, LondonSchoolofHygieneand TropicalMedicine,UnitedKingdom We tested associations between mother’s age at menarche, mother’s adult body size and obesity risk, and her children’s growth and obesity risk in 6,009 children from the UK population-basedAvonLongitudinalStudyofParentsandChildren(ALSPAC)birthcohortwho had growth and fat mass at age 9 y measured by dual-energy X-ray absorptiometry. A subgroupof914childrenalsohaddetailedinfancyandchildhoodgrowthdata.Inthemothers, earlier menarche was associated with shorter adult height (by 0.64 cm/y), increased weight (0.92kg/y),andbodymassindex(BMI,0.51kg/m2/y;allp,0.001).Incontrast,inherchildren, earliermother’smen